[Frontiers in Bioscience 3, d757-768, August 1, 1998]
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INTEGRIN-MEDIATED SIGNALING IN THE REGULATION OF OSTEOCLAST ADHESION AND ACTIVATION

Le T. Duong and Gideon A. Rodan

Department of Bone Biology and Osteoporosis, Merck Research Laboratories, West Point, PA 19486, USA

Received 1/16/98 Accepted 2/18/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Integrins: an overview
3.1. Proteins that associate with integrins
3.2. Integrin-mediated signal transduction
4. Integrins in Osteoclasts
4.1. Expression of integrins in osteoclasts
4.2. The vitronectin receptor alpha v beta 3
4.3. alpha v beta 3-mediated osteoclast function
5. Integrin-dependent signal transduction in osteoclasts
6. Perspective
7. Acknowledgement
8. References
9. Entire manuscript

Key words: Tyrosine Phosphorylation, Cytoskeleton, Sealing Zone, Bone Resorption, Vitronectin receptor alpha v beta 3

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