[Frontiers in Bioscience, 3, d136-151, February 1, 1998]
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CAVEAT LECTOR




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MECHANISM OF ACTION OF ANTIBODY TO CAPSULAR POLYSACCHARIDE IN CRYPTOCOCCUS NEOFORMANS INFECTION

Marta Feldmesser1 and Arturo Casadevall1,2

1Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology2, Albert Einstein College of Medicine, Golding Building Room 701, 1300 Morris Park Ave., Bronx, NY 10461

Received 1/5/98 Accepted 1/9/98

TABLE OF CONTENTS


1. Abstract
2. Introduction
3. Overview of pathogenesis and the host immune response
4. The polysaccharide capsule
4.1. Immunomodulatory effects
4.2. Antigenic characteristics

5. The Ab response to C. neoformans
5.1. Native Ab production
5.2. Ab response to infection and vaccination

6. Polyclonal Ab
7. mAbs to the capsule of C. neoformans
7.1. Description
7.2. The role of isotype

8. Potential mechanisms of Ab action
8.1. Opsonization/phagocytosis
8.2. Enhancement of macrophage effector functions (killing)
8.3. Granulocytes as effector cells
8.4. Altered antigen presentation
8.5. Antibody-dependent cell-mediated cytotoxicity
8.6. Removal of GXM
8.7. Altered pathology
8.8. Inconsistencies
8.9. New directions: Altered cytokine expression/cellular recruitment

9. Perspective
10. Acknowledgments
11. References
12. Entire manuscript

Key words: Cryptococcus neoformans, Antibody, Immunology, Monoclonal antibody, Polysaccharide, Capsule

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