[Frontiers in Bioscience 3, d684-700, July 2, 1998]
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REGULATION OF THE EXTRACELLULAR LIGAND BINDING ACTIVITY OF INTEGRINS

Catherine Fernandez , Katherine Clark, Louise Burrows, Neil R. Schofield, Martin J. Humphries

School of Biological Sciences, University of Manchester, Room 2.205 Stopford Building, Oxford Road, Manchester M13 9PT

Received 5/27/98 Accepted 6/8/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Integrin structure
3.1. Alpha subunit A-domain
3.2. Putative beta subunit A-domain
3.3. Alpha subunit N-terminal repeats
4. Ligand binding sites in integrins
4.1. Sites in alpha subunits
4.2. Sites in beta subunits
5. Use of divalent cations and monoclonal antibodies to probe conformational changes in integrin-ligand binding
5.1. Role of divalent cations
5.2. Conformation-dependent epitopes
6. Regulation of ligand binding mediated by inside-out signalling
6.1. Motifs within cytoplasmic domains
6.2. Inside-out regulation by cytoplasmic proteins
6.3. Inside-out regulation by membrane-anchored proteins
6.4. Intracellular signalling pathways
7. Perspective
8. References
9. Entire manuscript

Key words: Integrin, Structure, Ligand Binding Sites, Conformational Changes, Divalent Cations, Monoclonal Antibodies, Inside-Out Signalling

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