[Frontiers in Bioscience 3, d288-299, March 1, 1998]
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STRUCTURE AND FUNCTION OF HEPARIN-BINDING EGF-LIKE GROWTH FACTOR (HB-EGF)

Karen M. Davis-Fleischer, PhD and Gail E. Besner

Department of Surgery, Children’s Hospital and The Ohio State University, 700 Children’s Drive, Columbus, Ohio, 43205

Received 2/20/98 Accepted 2/25/98

TABLE OF CONTENTS


1.Abstract
2.Introduction
3. Discussion
3.1. HB-EGF Primary Structure
3.2.HB-EGF Gene Structure
3.2. HB-EGF Processing
3.4. HB-EGF Expression Patterns
3.5. HB-EGF Biology
3.5.1. Myogenesis
3.5.2. Reproductive Tract
3.5.3. Gastrointestinal Tract
3.5.4. Vasculature
3.5.5. Renal System
3.5.6. Urinary Tract
3.5.7. Hepatic System
3.5.8. Wound Healing
3.5.9. Carcinogenesis
3.6. HB-EGF Signaling

4. Summary
5. Acknowledgments
6. References
7. Entire manuscript

Key words: Diphtheria toxin, Diphtheria toxin receptor, EGF family, EGF receptor, ErbB-1/HER1, ErbB-4/HER4, Heparin-binding

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