[Frontiers in Bioscience 3, d399-407, March 26, 98]
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CELLULAR AND MOLECULAR BASIS OF -AMYLOID PRECURSOR PROTEIN METABOLISM

Jeffrey P. Greenfield,1,2, Gunnar K. Gouras,1,2, and Huaxi Xu2

1 Department of Neurology and Neuroscience, Cornell University Medical College and the 2 Fisher Center for Alzheimer's Research and Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York NY 10021

Received 3/12/98 Accepted 3/16/98

TABLE OF CONTENTS


1. Abstract
2. Introduction
3. Discussion
3.1. ßAPP Structure Gives Clues to its Function
3.1.1. ßAPP is Trafficked and Processed Through the Secretory Pathway
3.1.2. a-Secretase cleaves bAPP at the Cell Surface
3.1.3. Alternative ßAPP Metabolism Gives Rise to the Amyloid-ß Peptide
3.2. Intracellular Generation of Aß
3.2.1. Presenilin Mutations Support the Aß Hypothesis
3.3. Cellular Biology of APP Trafficking
3.3.1. Signal Transduction Regulates ßAPP Trafficking
3.3.2. Estrogen Regulates ßAPP Trafficking
4. Perspective
5. Acknowledgements
6. References
7. Entire manuscript

Key words: Alzheimer's disease, ß-amyloid precursor protein, ß-amyloid, Presenilin proteins, Intracellular trafficking, Signal transduction, Phosphorylation, Estrogen, Endoplasmic reticulum, Golgi, trans-Golgi Network

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