[Frontiers in Bioscience 3, d399-407, March 26, 98]

	[Frontiers in Bioscience 3, d399-407, March 26, 98] Reprints PubMed CAVEAT LECTOR
	CELLULAR AND MOLECULAR BASIS OF ß-AMYLOID PRECURSOR PROTEIN METABOLISM Jeffrey P. Greenfield,^1,2, Gunnar K. Gouras,^1,2, and Huaxi Xu² 1 Department of Neurology and Neuroscience, Cornell University Medical College and the ²Fisher Center for Alzheimer's Research and Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York NY 10021 Received 3/12/98 Accepted 3/16/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Discussion 3.1. ßAPP Structure Gives Clues to its Function 3.1.1. ßAPP is Trafficked and Processed Through the Secretory Pathway 3.1.2. a-Secretase cleaves bAPP at the Cell Surface 3.1.3. Alternative ßAPP Metabolism Gives Rise to the Amyloid-ß Peptide 3.2. Intracellular Generation of Aß 3.2.1. Presenilin Mutations Support the Aß Hypothesis 3.3. Cellular Biology of APP Trafficking 3.3.1. Signal Transduction Regulates ßAPP Trafficking 3.3.2. Estrogen Regulates ßAPP Trafficking 4. Perspective 5. Acknowledgements 6. References 7. Entire manuscript Key words: Alzheimer's disease, ß-amyloid precursor protein, ß-amyloid, Presenilin proteins, Intracellular trafficking, Signal transduction, Phosphorylation, Estrogen, Endoplasmic reticulum, Golgi, trans-Golgi Network Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d399-407, March 26, 98]
Reprints
PubMed
CAVEAT LECTOR

CELLULAR AND MOLECULAR BASIS OF ß-AMYLOID PRECURSOR PROTEIN METABOLISM

Jeffrey P. Greenfield,^1,2, Gunnar K. Gouras,^1,2, and Huaxi Xu²

1 Department of Neurology and Neuroscience, Cornell University Medical College and the ²Fisher Center for Alzheimer's Research and Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York NY 10021

Received 3/12/98 Accepted 3/16/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion: 3.1. ßAPP Structure Gives Clues to its Function
3.1.1. ßAPP is Trafficked and Processed Through the Secretory Pathway
3.1.2. a-Secretase cleaves bAPP at the Cell Surface
3.1.3. Alternative ßAPP Metabolism Gives Rise to the Amyloid-ß Peptide
3.2. Intracellular Generation of Aß
3.2.1. Presenilin Mutations Support the Aß Hypothesis
3.3. Cellular Biology of APP Trafficking
3.3.1. Signal Transduction Regulates ßAPP Trafficking
3.3.2. Estrogen Regulates ßAPP Trafficking
4. Perspective
5. Acknowledgements
6. References
7. Entire manuscript

Key words: Alzheimer's disease, ß-amyloid precursor protein, ß-amyloid, Presenilin proteins, Intracellular trafficking, Signal transduction, Phosphorylation, Estrogen, Endoplasmic reticulum, Golgi, trans-Golgi Network

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.