[Frontiers in Bioscience 3, d657-664, July 1, 1998]
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CD44 EXPRESSION AND GROWTH FACTORS

Jun-ichi Hamada1, Yutaka Sawamura2, and Erwin G. Van Meir3

1 Division of Cell Biology, Cancer Institute and 2 Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan, 3 Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Center, Emory University, Atlanta, Georgia, 30322, U.S.A. and 3 Laboratory of Tumor Biology and Genetics, Neurosurgery Department, University Hospital, 1011 Lausanne, Switzerland

Received 4/18/98 Accepted 5/15/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Alteration of CD44 expression by the stimulation with growth factors and cytokines
4. Signal transduction pathways involved in the upregulation of CD44 by growth factor-stimulation
5. Presentation of growth factors and cytokines by CD44
6. Influence of growth factors and cytokines on the production of hyaluronan, a principal ligand of CD44
7. The roles of CD44 in peritoneal dissemination
8. References
9. Entire manuscript

Key words: CD44, Tumor, Metastasis, Growth factor

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