[Frontiers in Bioscience 3, d657-664, July 1, 1998]

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Jun-ichi Hamada1, Yutaka Sawamura2, and Erwin G. Van Meir3

1 Division of Cell Biology, Cancer Institute and 2 Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan, 3 Laboratory of Molecular Neuro-Oncology, Neurosurgery Department and Winship Cancer Center, Emory University, Atlanta, Georgia, 30322, U.S.A. and 3 Laboratory of Tumor Biology and Genetics, Neurosurgery Department, University Hospital, 1011 Lausanne, Switzerland

Received 4/18/98 Accepted 5/15/98


1. Abstract
2. Introduction
3. Alteration of CD44 expression by the stimulation with growth factors and cytokines
4. Signal transduction pathways involved in the upregulation of CD44 by growth factor-stimulation
5. Presentation of growth factors and cytokines by CD44
6. Influence of growth factors and cytokines on the production of hyaluronan, a principal ligand of CD44
7. The roles of CD44 in peritoneal dissemination
8. References
9. Entire manuscript

Key words: CD44, Tumor, Metastasis, Growth factor

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