[Frontiers in Bioscience 3, d1274-1279. December 15, 1998]
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NEUROENDOCRINE AND IMMUNE MEDIATORS IN PROSTATE CANCER PROGRESSION

Naseema M. Hoosein

The University of Texas, M. D. Anderson Cancer Center, Genitourinary Oncology, Box 155, 1515 Holcombe Blvd., Houston, TX 77030

Received 11/30/98 Accepted 12/4/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3.The neuroendocrine phenotype and androgen-independent prostate cancer.
4. Immune mediators can modulate prostate cancer proliferation.
5. Immune mediators can modulate expression of exocrine and neuroendocrine markers.
6. Relationship between interleukin-1 and bone metastasis
7. Increased ß-2 microglobulin (ß-2m) shedding in metastatic prostate cancer.
8. Perspective
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Prostate, Neuroendocrine, Cancer, Cytokine, Interleukin-1, Beta-2 microglobulin