[Frontiers in Bioscience 3, d509-516, May 26, 1998]

	[Frontiers in Bioscience 3, d509-516, May 26, 1998] Reprints PubMed CAVEAT LECTOR
	NATURAL SELECTION AND THE EVOLUTIONARY HISTORY OF MAJOR HISTOCOMPATIBILITY COMPLEX LOCI Austin L. Hughes and Meredith Yeager Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park PA 16802 USA Received 5/11/98 Accepted 5/22/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Balancing selection at MHC loci 3.1. Explaining MHC polymorphism 3.2 Trans-species polymorphism 4. Duplication of loci 5. The role of recombination 5.1. Intralocus recombination in the class I MHC 5.2 intralocus recombination the class II MHC 6. Acknowledgments 7. References 8. Entire manuscript Key words: HLA-DR, Major histocompatibility complex, MHC, T cells, polymorphism Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d509-516, May 26, 1998]
Reprints
PubMed
CAVEAT LECTOR

NATURAL SELECTION AND THE EVOLUTIONARY HISTORY OF MAJOR HISTOCOMPATIBILITY COMPLEX LOCI

Austin L. Hughes and Meredith Yeager

Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park PA 16802 USA

Received 5/11/98 Accepted 5/22/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Balancing selection at MHC loci: 3.1. Explaining MHC polymorphism
3.2 Trans-species polymorphism
4. Duplication of loci
5. The role of recombination: 5.1. Intralocus recombination in the class I MHC
5.2 intralocus recombination the class II MHC
6. Acknowledgments
7. References
8. Entire manuscript

Key words: HLA-DR, Major histocompatibility complex, MHC, T cells, polymorphism

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.