[Frontiers in Bioscience 3, d509-516, May 26, 1998]
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NATURAL SELECTION AND THE EVOLUTIONARY HISTORY OF MAJOR HISTOCOMPATIBILITY COMPLEX LOCI

Austin L. Hughes and Meredith Yeager

Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park PA 16802 USA

Received 5/11/98 Accepted 5/22/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Balancing selection at MHC loci
3.1. Explaining MHC polymorphism
3.2 Trans-species polymorphism
4. Duplication of loci
5. The role of recombination
5.1. Intralocus recombination in the class I MHC
5.2 intralocus recombination the class II MHC
6. Acknowledgments
7. References
8. Entire manuscript

Key words: HLA-DR, Major histocompatibility complex, MHC, T cells, polymorphism

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