[Frontiers in Bioscience 3, d313-324, March 15, 1998]
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REGULATION OF SURVIVAL PATHWAYS BY IL-3 AND INDUCTION OF APOPTOSIS FOLLOWING IL-3 WITHDRAWAL

Daniel E. Johnson

Departments of Medicine and Pharmacology, University of Pittsburgh, and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

Received 1/30/97 Accepted 2/27/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Signals mediated by the IL-3 receptor
4. Bcl-2, Bad, and Akt kinase
5. Mitochondrial changes during apoptosis
6. Activation of caspase proteases following IL-3 withdrawal
7. The importance of p53
8. Perspectives
9. Acknowledgements
10. References
11. Entire manuscript

Key words: Apoptosis, Hematopoietic cells, IL-3, Bcl-2, Bad, Cytochrome c, Caspases

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