[Frontiers in Bioscience, 3, d447-458, April 27, 1998]
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CAVEAT LECTOR




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ROLE OF E2F IN CELL CYCLE CONTROL AND CANCER

David G. Johnson and Robin Schneider-Broussard

The University of Texas M. D. Anderson Cancer Center, Science Park-Research, Division, Department of Carcinogenesis, P.O. Box 389, Smithville, TX 78957

Received 4/1/98 Accepted 4/20/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. The E2F family
3.2. Regulation of E2F factors by the Rb family of pocket proteins
3.3. Transcriptional repression by E2F
3.4. Regulation of E2F activity by other factors
3.5. Control of S-phase entry and apoptosis by E2F
3.6. Role of E2F in cancer
4. Acknowledgments
5. References
6. Entire manuscript

Key words: E2F, DP, cell cycle, Rb, Pocket Protein, Transcriptional Repression, S-Phase, Apoptosis, Transcriptional Regulation, Cancer