[Frontiers in Bioscience 3, d100-112, January 15, 1998]
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CAVEAT LECTOR




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ALZHEIMER'S DISEASE AND BRAIN DEVELOPMENT: COMMON MOLECULAR PATHWAYS

Kelly Jordan-Sciutto and Robert Bowser

Department of Pathology, University of Pittsburgh School of Medicine. Pittsburgh, PA 15261

Received 11/9/97 Accepted 11/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1. The Amyloid Hypothesis
2.2. The Presenilins, Support of the Amyloid Hypothesis
2.3. Cytoskeletal Abnormalities
2.4. Alternate Pathways

3. Genes alternatively expressed in AD
3.1. Transcription Factors
3.2. Cell Cycle Genes in AD
3.3. Developmentally Regulated Genes

4. Perspective
5. Acknowledgments
6. References
7. Entire manuscript

Key words: Alzheimer's disease, Development, Gene expression, Cell cycle, Transcription

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