[Frontiers in Bioscience 3, d795-803, August 1, 1998]
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ROLE OF PTHrP AND PTH-1 RECEPTOR IN ENDOCHONDRAL BONE DEVELOPMENT

Andrew C. Karaplis and Ron A. Deckelbaum

Division of Endocrinology, Department of Medicine, and Lady Davis Institute for Medical Research, McGill University, Montréal, Canada

Received 2/16/98 Accepted 3/23/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. PTHrP and PTH-1 receptor in chondrocyte biology
3.1. The endochondral skeleton
3.2. Chondrocyte differentiation
3.3. Chondrocyte apoptosis
3.4. The hedgehog proteins
3.5. The role of other cytokines
3.6. Clarifying the role of the PTH-1 receptor
4. PTHrP and PTH-1 receptor in osteoblast biology
4.1. PTHrP haploinsufficiency and osteopenia
4.2. Induction of osteogenic differentiation by Hh proteins
4.3. PTHrP and bone remodeling
4.4. Potential therapy for osteoporosis
5. Perspective
6. Acknowledgments
7. References
8. Entire manuscript

Key words: Review, PTHrP signaling, Endochondral ossification, Skeletal dysplasia, Chondrocytes, Osteoblasts

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