[Frontiers in Bioscience 3, d795-803, August 1, 1998]

	[Frontiers in Bioscience 3, d795-803, August 1, 1998] Reprints PubMed CAVEAT LECTOR
	ROLE OF PTHrP AND PTH-1 RECEPTOR IN ENDOCHONDRAL BONE DEVELOPMENT Andrew C. Karaplis and Ron A. Deckelbaum Division of Endocrinology, Department of Medicine, and Lady Davis Institute for Medical Research, McGill University, Montréal, Canada Received 2/16/98 Accepted 3/23/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. PTHrP and PTH-1 receptor in chondrocyte biology 3.1. The endochondral skeleton 3.2. Chondrocyte differentiation 3.3. Chondrocyte apoptosis 3.4. The hedgehog proteins 3.5. The role of other cytokines 3.6. Clarifying the role of the PTH-1 receptor 4. PTHrP and PTH-1 receptor in osteoblast biology 4.1. PTHrP haploinsufficiency and osteopenia 4.2. Induction of osteogenic differentiation by Hh proteins 4.3. PTHrP and bone remodeling 4.4. Potential therapy for osteoporosis 5. Perspective 6. Acknowledgments 7. References 8. Entire manuscript Key words: Review, PTHrP signaling, Endochondral ossification, Skeletal dysplasia, Chondrocytes, Osteoblasts Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d795-803, August 1, 1998]
Reprints
PubMed
CAVEAT LECTOR

ROLE OF PTHrP AND PTH-1 RECEPTOR IN ENDOCHONDRAL BONE DEVELOPMENT

Andrew C. Karaplis and Ron A. Deckelbaum

Division of Endocrinology, Department of Medicine, and Lady Davis Institute for Medical Research, McGill University, Montréal, Canada

Received 2/16/98 Accepted 3/23/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. PTHrP and PTH-1 receptor in chondrocyte biology: 3.1. The endochondral skeleton
3.2. Chondrocyte differentiation
3.3. Chondrocyte apoptosis
3.4. The hedgehog proteins
3.5. The role of other cytokines
3.6. Clarifying the role of the PTH-1 receptor
4. PTHrP and PTH-1 receptor in osteoblast biology: 4.1. PTHrP haploinsufficiency and osteopenia
4.2. Induction of osteogenic differentiation by Hh proteins
4.3. PTHrP and bone remodeling
4.4. Potential therapy for osteoporosis
5. Perspective
6. Acknowledgments
7. References
8. Entire manuscript

Key words: Review, PTHrP signaling, Endochondral ossification, Skeletal dysplasia, Chondrocytes, Osteoblasts

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.