[Frontiers in Bioscience 3, d834-837, August 1, 1998]
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TRANSCRIPTIONAL REGULATION OF OSTEOBLAST DIFFERENTIATION DURING DEVELOPMENT

Gerard Karsenty

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030

Received 2/18/98 Accepted 3/23/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Characterization of Osf2 as an osteoblast-specific transcript of Cbfa1
4. Osf2/Cbfa1 regulates osteoblast development from mesenchymal precursors
5. Phenotype of Cbfa1+/- mice
6. The genetic basis for the human CCD syndrome
7. Perspectives
8. References
9. Entire manuscript

Key words: Osf2/Cbfa1, Osteoblast differentiation, Molecular genetics

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