Warren Knudson

Department of Biochemistry, Department of Pathology, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612-3864

Received 4/27/98, Accepted 5/15/98

TABLE OF CONTENTS

1. Abstract

2. Introduction

3. Tumor-associated hyaluronan

3.1. Structure and synthesis of tumor-associated hyaluronan
3.2. Preferential enrichment of tumor tissue with hyaluronan
3.3. Is the level of hyaluronan content in tumor progression of diagnostic or prognostic value?

4. The function of tumor-associated hyaluronan

4.1. Hyaluronan and cell migration: A function by association
4.2. Proposed mechanisms for the involvement of hyaluronan in cell migration and proliferation

5. The role of CD44 as a hyaluronan receptor during tumor progression

6. Acknowledgments

7. References

8. Entire manuscript