[Frontiers in Bioscience 3, d821-833, August 1, 1998]
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CAVEAT LECTOR




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TRANSCRIPTIONAL ACTIVATION THROUGH THE VITAMIN D RECEPTOR IN OSTEOBLASTS

Dennis M. Kraichely and Paul N. MacDonald

Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, St. Louis, Missouri 63104

Received 3/25/98 Accepted 5/6/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Structural and functional aspects of the VDR
3.1 N-terminal A/B domain
3.2. The DNA binding domain
3.3. The hinge region
3.4. The multifunctional LBD
3.4.1. Ligand binding
3.4.2. RXR heterodimerization
3.4.3. VDR phosphorylation
3.4.4. The AF-2 helix, a ligand-dependent transactivation domain
4. Mechanisms involved in VDR-mediated transactivation
4.1. VDR interactions with GTFs
4.2. VDR interactions with TAFIIs
4.3. VDR interactions with nuclear receptor coactivator proteins
4.4. Mechanisms of VDR-coactivator interactions
4.5. VDR interactions with nuclear receptor corepressor proteins
5. Model of VDR-mediated transcription in osteoblasts
6. Acknowledgments
7. References
8. Entire manuscript

Key words: VDR, Osteoblasts, Transactivation, AF-2 domain, Nuclear Receptor, Coactivator, Corepressor

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