[Frontiers in Bioscience 3, d616-630, July 1, 1998]
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CAVEAT LECTOR




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CD44 STRUCTURE AND FUNCTION

Jayne Lesley and Robert Hyman

Cancer Biology Laboratory, The Salk Institute for Biological Studies, P.O. Box 85800, San Diego CA 92186-5800

Received 4/27/98 Accepted 5/15/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. The extracellular domain
3.1. The conserved region
3.1.1. The link module
3.1.2. N-glycosylation sites
3.1.3. Outside the link module
3.2 The non-conserved region
3.2.1. Carbohydrate modifications
3.2.2. Variable sequences
3.2.3 Soluble CD44
4. The transmembrane domain
4.1 Insolubility in nonionic detergents
4.2 Palmitoylation and dimerization
5. The cytoplasmic domain
5.1. Regulation of ligand binding
5.2. Phosphorylation
5.3. Localization in the plasma membrane
5.4. Association with the cytoskeleton
5.4.1. Association with ankyrin
5.4.2. Association with microfilaments
5.5. Signal transduction
6. Perspectives
7. Acknowledgments
8. References
9. Entire manuscript

Key words: CD44, Hyaluronan Binding, Phosphorylation, Activation States, Glycosylation, Cytoplasmic Domain, Transmembrane Domain

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