[Frontiers in Bioscience 3, d631-636, July 1, 1998]
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MECHANISMS REGULATING THE BINDING ACTIVITY OF CD44 TO HYALURONIC ACID

Dacai Liu, Tong Liu, Ruliang, Li, and Man-Sun Sy

Institute of Pathology, Cancer Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44120

Received 4/27/98 Accepted 5/12/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Interactions CD on Jurkat T cells and soluble HA
3.1. Binding of CD44 to ha requires cellular activation in Jurkat T cells
3.2. The transmembrane domain of CD44 is essential for binding of HA
3.3. Interactions between the cytoplasmic domain of CD44 and cytoskeletal proteins are also important in binding of CD44 to HA
4. Perspective
5. References
6. Entire manuscript

Key words: CD44, Hyaluronic acid, Protein, Review, Adhesion molecule, Mutagenesis

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