[Frontiers in Bioscience 3, d1148-1160, November 15, 1998]
Reprints
PubMed
CAVEAT LECTOR



Table of Conents
Previous Section Next Section

MOLECULAR PATHOBIOLOGY OF PANCREATIC ADENOCARCINOMA

Shamlal Mangray and Thomas C King

Department of Pathology and Laboratory Medicine, Brown University School of Medicine, Providence, RI

Received 8/24/98 Accepted 9/4/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Heritable pancreatic cancer
3.1. Genetic syndromes predisposing to pancreatic adenocarcinoma
3.1.1. Hereditary pancreatitis
3.1.2. Ataxia telangiectasia
<3.1.3. FAMMM syndrome
3.1.4. Hereditary nonpolyposis colorectal cancer
3.1.5. Peutz-Jegher's syndrome
3.2. Familial pancreatic cancer
3.3. Pancreatic adenocarcinoma risk in families with other sporadic cancers
4. Chromosomal abnormalities in pancreatic adenocarcinoma
5. Genetic alterations in pancreatic adenocarcinoma
5.1. K-ras proto-oncogene
<5.2. p16INK4a /p15INK4b/p19ARF tumor suppressor genes
5.3. p53 tumor suppressor gene
<5.4. DPC4 (Smad4) tumor suppressor gene
5.5. FHIT, fragile histidine triad, candidate tumor suppressor gene
<5.6. HER-2/neu (erbB2) proto-oncogene
<5.7. BRCA2, hereditary breast Cancer
5.8. Rb1, retinoblastoma tumor suppressor gene
6. Diagnostic implications
7. Therapeutic implications
8. Perspective
9. References
10. Entire manuscript

Key words: Pancreatic Adenocarcinoma, Molecular Biology, p16, p53, K-ras, FHIT

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.

Enter one or more search keywords:

To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most