[Frontiers in Bioscience 3, d1-10, January 1, 1998]
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ASCORBATE FUNCTION AND METABOLISM IN THE HUMAN ERYTHROCYTE

James M. May

Departments of Medicine and Molecular Physiology and Biophysics, 736 Medical Research Building II, Vanderbilt University School of Medicine, Nashville, TN 37232-6303 USA

Received 11/5/97 Accepted 11/9/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Redox chemistry of ascorbic acid
4. Erythrocyte uptake of ascorbate and DHA
5. Ascorbate recycling in erythrocytes: mechanisms and capacity
5.1. Mechanisms of erythrocyte ascorbate recycling
5.2. Capacity of erythrocytes for ascorbate recycling

6. Antioxidant function of ascorbate in plasma and in erythrocytes
6.1. Ascorbate as an antioxidant in plasma
6.2. Role of ascorbate in protecting erythrocytes from oxidative stress

7. Perspective
8. Acknowledgments
9. References
10. Entire manuscript

Key words: Ascorbic acid, Alpha-tocopherol, Oxidant stress, Antioxidant Metabolism, Glutathione, Human erythrocytes.

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