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ASCORBATE FUNCTION AND METABOLISM IN THE HUMAN ERYTHROCYTE
James M. May
Departments of Medicine and Molecular Physiology and Biophysics, 736 Medical Research Building II, Vanderbilt University School of Medicine, Nashville, TN 37232-6303 USA
Received 11/5/97 Accepted 11/9/97
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Redox chemistry of ascorbic acid
- 4. Erythrocyte uptake of ascorbate and DHA
- 5. Ascorbate recycling in erythrocytes: mechanisms and capacity
- 5.1. Mechanisms of erythrocyte ascorbate recycling
5.2. Capacity of erythrocytes for ascorbate recycling
- 6. Antioxidant function of ascorbate in plasma and in erythrocytes
- 6.1. Ascorbate as an antioxidant in plasma
6.2. Role of ascorbate in protecting erythrocytes from oxidative stress
- 7. Perspective
- 8. Acknowledgments
- 9. References
- 10. Entire manuscript
Key words: Ascorbic acid, Alpha-tocopherol, Oxidant stress, Antioxidant Metabolism, Glutathione, Human erythrocytes.
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