![]()
|
[Frontiers in Bioscience 3, d11-24, January 1, 1998] Reprints PubMed CAVEAT LECTOR |
|
|---|---|---|
![]() ![]() ![]()
|
THE P130 POCKET PROTEIN: KEEPING ORDER AT CELL CYCLE EXIT/RE-ENTRANCE TRANSITIONS Xavier Mayol and Xavier Grana Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry and Temple University School of Medicine. 3307 North Broad St., Philadelphia, PA19140 Received 12/5/97 Accepted 12/9/97 6. REFERENCES 1. La Thangue, N. B.: E2F and the molecular mechanisms of early cell-cycle control. Biochem. Soc. Trans. 24, 54-9 (1996) 2. Slansky, J. E. and Farnham, P. J.: Introduction to the E2F family: protein structure and gene regulation. Curr. Top. Microbiol. Immunol. 208, 1-30 (1996) 3. Ohtani, K., DeGregori, J. and Nevins, J. R.: Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA 92, 12146-50 (1995) 4. Botz, J., Zerfass-Thome, K., Spitkovsky, D., Delius, H., Vogt, B., Eilers, M., Hatzigeorgiou, A. and Jansen-Durr, P.: Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol. 16, 3401-9 (1996) 5. Geng, Y., Eaton, E. N., Picon, M., Roberts, J. M., Lundberg, A. S., Gifford, A., Sardet, C. and Weinberg, R. A.: Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12, 1173-80 (1996) 6. Huet, X., Rech, J., Plet, A., Vie, A. and Blanchard, J. M.: Cyclin A expression is under negative transcriptional control during the cell cycle. Mol. Cell. Biol. 16, 3789-98 (1996) 7. Schulze, A., Zerfass, K., Spitkovsky, D., Middendorp, S., Berges, J., Helin, K., Jansen-Durr, P. and Henglein, B.: Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc. Natl. Acad. Sci. USA 92, 11264-8 (1995) 8. Dalton, S.: Cell cycle regulation of the human cdc2 gene. EMBO J. 11, 1797-804 (1992) 9. Tommasi, S. and Pfeifer, G. P.: In vivo structure of the human cdc2 promoter: Release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol. Cell. Biol. 15, 6901-6913 (1995) 10. Zwicker, J., Lucibello, F. C., Wolfraim, L. A., Gross, C., Truss, M., Engeland, K. and Muller, R.: Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J. 14, 4514-22 (1995) 11. Zwicker, J., Liu, N., Engeland, K., Lucibello, F. C. and Muller, R.: Cell cycle regulation of E2F site occupation in vivo. Science 271, 1595-7 (1996) 12. Lam, E. W. and Watson, R. J.: An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J. 12, 2705-13 (1993) 13. Thalmeier, K., Synovzik, H., Mertz, R., Winnacker, E. L. and Lipp, M.: Nuclear factor E2F mediates basic transcription and trans-activation by E1A of the human MYC promoter. Genes Dev. 3, 527-36 (1989) 14. Hiebert, S. W., Lipp, M. and Nevins, J. R.: E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA 86, 3594-8 (1989) 15. Zhu, L., Zhu, L., Xie, E. and Chang, L. S.: Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol. Cell. Biol. 15, 3552-3562 (1995) 16. Johnson, D. G., Ohtani, K. and Nevins, J. R.: Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8, 1514-25 (1994) 17. Smith, E. J., Leone, G., Degregori, J., Jakoi, L. and Nevins, J. R.: The accumulation of an E2F-p130 transcriptional repressor distinguishes a G(0) cell state from a G(1) cell state. Mol. Cell. Biol. 16, 6965-6976 (1996) 18. Hsiao, K. M., McMahon, S. L. and Farnham, P. J.: Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev. 8, 1526-37 (1994) 19. Neuman, E., Flemington, E. K., Sellers, W. R. and Kaelin, W. J.: Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 14, 6607-6615 (1994) 20. Sears, R., Ohtani, K. and Nevins, J. R.: Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol. Cell. Biol. 17, 5227-5235 (1997) 21. Johnson, L. F.: G1 events and the regulation of genes for S-phase enzymes. Curr. Opin. Cell. Biol. 4, 149-54 (1992) 22. Means, A. L., Slansky, J. E., McMahon, S. L., Knuth, M. W. and Farnham, P. J.: The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter. Mol. Cell. Biol. 12, 1054-63 (1992) 23. Slansky, J. E., Li, Y., Kaelin, W. G. and Farnham, P. J.: A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13, 1610-8 (1993) 24. Pearson, B. E., Nasheuer, H. P. and Wang, T. S.: Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells. Mol. Cell. Biol. 11, 2081-95 (1991) 25. Ogris, E., Rotheneder, H., Mudrak, I., Pichler, A. and Wintersberger, E.: A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene. J. Virol. 67, 1765-71 (1993) 26. DeGregori, J., Kowalik, T. and Nevins, J. R.: Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell. Biol. 15, 4215-4224 (1995) 27. Ohtani, K., Degregori, J., Leone, G., Herendeen, D. R., Kelly, T. J. and Nevins, J. R.: Expression of the HsORC1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol. Cell. Biol. 16, 6977-6984 (1996) 28. Mayol, X. and Grana, X.: pRB, p107 and p130 as transcriptional regulators: Role in cell growth and differentiation. In: Progress in Cell Cycle Research, vol. 3 (Meijier, L. G., S. and Philippe, M., ed.), pp. 157-169, Plenum Press, New York (1997) 29. Dynlacht, B. D., Moberg, K., Lees, J. A., Harlow, E. and Zhu, L.: Specific regulation of E2F family members by Cyclin-Dependent Kinases. Mol. Cell. Biol. 17, 3867-3875 (1997) 30. Lindeman, G. J., Gaubatz, S., Livingston, D. M. and Ginsberg, D.: The subcellular localization of E2F-4 is cell-cycle dependent. Proc. Natl. Acad. Sci. USA 94, 5095-5100 (1997) 31. Muller, H., Moroni, M. C., Vigo, E., Petersen, B. O., Bartek, J. and Helin, K.: Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol. Cell. Biol. 17, 5508-5520 (1997) 32. De la Luna, S., Burden, M. J., Lee, C. W. and La Thangue, N. B.: Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal. J. Cell Sci. 109, 2443-2452 (1996) 33. Verona, R., Moberg, K., Estes, S., Starz, M., Vernon, J. P. and Lees, J. A.: E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17, 7268-7282 (1997) 34. Adams, P. D., Sellers, W. R., Sharma, S. K., Wu, A. D., Nalin, C. M. and Kaelin, W. G.: Identification of a Cyclin-Cdk2 recognition motif present in substrates and p21-Like Cyclin-Dependent Kinase Inhibitors. Mol. Cell. Biol. 16, 6623-6633 (1996) 35. Woo, M. S. A., Sanchez, I. and Dynlacht, B. D.: p130 and p107 use a conserved domain to inhibit cellular Cyclin-Dependent Kinase activity. Mol. Cell. Biol. 17, 3566-3579 (1997) 36. De Luca, A., Maclachlan, T. K., Bagella, L., Dean, C., Howard, C. M., Claudio, P. P., Baldi, A., Khalili, K. and Giordano, A.: A unique domain of pRb2/p130 acts as an Inhibitor of Cdk2 Kinase activity. J. Biol. Chem. 272, 20971-20974 (1997) 37. Zhu, L., Harlow, E. and Dynlacht, B. D.: p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9, 1740-1752 (1995) 38. Hurford, R. K., Cobrinik, D., Lee, M. H. and Dyson, N.: pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11, 1447-1463 (1997) 39. Wells, J. M., Illenye, S., Magae, J., Wu, C. L. and Heintz, N. H.: Accumulation of E2F-4-DP-1 DNA Binding Complexes Correlates with Induction of Dhfr Gene Expression During the G(1) to S Phase Transition. J. Biol. Chem. 272, 4483-4492 (1997) 40. Tao, Y., Kassatly, R. F., Cress, W. D. and Horowitz, J. M.: Subunit composition determines E2F DNA-binding site specificity. Mol. Cell. Biol. 17, 6994-7007 (1997) 41. Zwicker, J. and Muller, R.: Cell-cycle regulation of gene expression by transcriptional repression. Tren. Genet. 13, 3-6 (1997) 42. Vairo, G., Livingston, D. M. and Ginsberg, D.: Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev. 9, 869-881 (1995) 43. Moberg, K., Starz, M. A. and Lees, J. A.: E2F-4 switches from p130 to p107 and pRb in response to cell cycle Reentry. Mol. Cell. Biol. 16, 1436-1449 (1996) 44. Ikeda, M., Jakoi, L. and Nevins, J. R.: A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA 93, 3215-3220 (1996) 45. Cobrinik, D., Whyte, P., Peeper, D. S., Jacks, T. and Weinberg, R. A.: Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 7, 2392-404 (1993) 46. Johnson, D. G.: Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. Oncogene 11, 1685-1692 (1995) 47. Wolf, D. A., Hermeking, H., Albert, T., Herzinger, T., Kind, P. and Eick, D.: A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation. Oncogene 10, 2067-2078 (1995) 48. Corbeil, H. B. and Branton, P. E.: Characterization of an E2F-p130 complex formed during growth arrest. Oncogene 15, 657-668 (1997) 49. Williams, C. D., Linch, D. C., Watts, M. J. and Thomas, N. S. B.: Characterization of cell cycle status and E2F complexes In mobilized Cd34(+) cells before and after cytokine stimulation. Blood 90, 194-203 (1997) 50. Williams, C. D., Linch, D. C., Sorensen, T. S., La Thangue, N. B. and Thomas, N. S. B.: The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130. Brit.J. Haematol. 96, 688-696 (1997) 51. Shin, E. K., Shin, A., Paulding, C., Schaffhausen, B. and Yee, A. S.: Multiple changes in E2F function and regulation occur upon muscle differentiation. Mol. Cell. Biol. 15, 2252-2262 (1995) 52. Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D. and Lassar, A. B.: Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267, 1018-1021 (1995) 53. Corbeil, H. B., Whyte, P. and Branton, P. E.: Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Oncogene 11, 909-920 (1995) 54. Kiess, M., Gill, R. M. and Hamel, P. A.: Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation. Cell. Growth differ. 6, 1287-1298 (1995) 55. Richon, V. M., Lyle, R. E. and McGehee, R. E.: Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation. J. Biol. Chem. 272, 10117-10124 (1997) 56. Jiang, H. P., Lin, J., Young, S. M., Goldstein, N. I., Waxman, S., Davila, V., Chellappan, S. P. and Fisher, P. B.: Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate. Oncogene 11, 1179-1189 (1995) 57. Mayol, X., Garriga, J. and Grana, X.: Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130. Oncogene 11, 801-808 (1995) 58. Mayol, X., Garriga, J. and Grana, X.: G1 Cyclin/Cdk-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4. Oncogene 13, 237-246 (1996) 59. Pardee, A. B.: G1 events and regulation of cell proliferation. Science 246, 603-8 (1989) 60. Johnson, D. G., Schwarz, J. K., Cress, W. D. and Nevins, J. R.: Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349-52 (1993) 61. Wu, X. and Levine, A. J.: p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91, 3602-6 (1994) 62. Qin, X. Q., Livingston, D. M., Kaelin, W. G., Jr. and Adams, P. D.: Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91, 10918-10922 (1994) 63. DeGregori, J., Leone, G., Ohtani, K., Miron, A. and Nevins, J. R.: E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9, 2873-87 (1995) 64. Kowalik, T. F., DeGregori, J., Schwarz, J. K. and Nevins, J. R.: E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69, 2491-2500 (1995) 65. Shan, B. and Lee, W. H.: Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14, 8166-8173 (1994) 66. Lukas, J., Petersen, B. O., Holm, K., Bartek, J. and Helin, K.: Deregulated expression of E2F family members induces S-phase entry and overcomes p16(Ink4a)-mediated growth suppression. Mol. Cell. Biol. 16, 1047-1057 (1996) 67. Mann, D. J. and Jones, N. C.: E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest. Curr. Biol. 6, 474-483 (1996) 68. Schwarz, J. K., Bassing, C. H., Kovesdi, I., Datto, M. B., Blazing, M., George, S., Wang, X. F. and Nevins, J. R.: Expression of the E2F1 transcription factor overcomes type Beta transforming growth factor-mediated growth suppression. Proc. Natl. Acad. Sci. USA 92, 483-487 (1995) 69. Shan, B., Farmer, A. A. and Lee, W. H.: The molecular basis of E2F-1/DP-1-induced S-phase entry and apoptosis. Cell. Growth differ. 7, 689-97 (1996) 70. Herrera, R. E., Sah, V. P., Williams, B. O., Makela, T. P., Weinberg, R. A. and Jacks, T.: Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16, 2402-7 (1996) 71. Herber, B., Truss, M., Beato, M. and Muller, R.: Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9, 1295-304 (1994) 72. Grana, X. and Reddy, E. P.: Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11, 211-219 (1995) 73. Lukas, J., Herzinger, T., Hansen, K., Moroni, M. C., Resnitzky, D., Helin, K., Reed, S. I. and Bartek, J.: Cyclin E-Induced S Phase without Activation of the pRb/E2F Pathway. Genes Dev. 11, 1479-1492 (1997) 74. Zerfass-Thome K., Schulze A., Zwerschke W., Vogt B., Helin K., Bartek J., Henglein B., Jansen-Durr P.: p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell Biol. 17, 407-415 (1997) 75. Beijersbergen, R. L., Carlee, L., Kerkhoven, R. M. and Bernards, R.: Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 9, 1340-1353 (1995) 76. Garriga, J., Limon, A., Mayol, X., Rane, S. G., Albrecht, J. H., Reddy, E. P., Andres, V. and Grana, X.: Differential regulation of pocket proteins during cell proliferation and differentiation. (Submitted) (1997) 77. Cobrinik, D., Lee, M. H., Hannon, G., Mulligan, G., Bronson, R. T., Dyson, N., Harlow, E., Beach, D., Weinberg, R. A. and Jacks, T.: Shared role of the pRb-related p130 and p107 proteins in limb development. Genes Dev. 10, 1633-1644 (1996) 78. Weinberg, R. A.: The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995) 79. Hateboer, G., Kerkhoven, R. M., Shvarts, A., Bernards, R. and Beijersbergen, R. L.: Degradation of E2F by the ubiquitin-proteasome pathway - regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev. 10, 2960-2970 (1996) 80. Puri, P. L., Balsano, C., Burgio, V. L., Chirillo, P., Natoli, G., Ricci, L., Mattei, E., Graessmann, A. and Levrero, M.: MyoD prevents cyclin a CDK2 containing E2F complexes formation in terminally differentiated myocytes. Oncogene 14, 1171-1184 (1997) 81. Hauser, P. J., Agrawal, D., Chu, B. K. and Pledger, W. J.: p107 and p130 associated cyclin A has altered substrate specificity. J. Biol. Chem. 272, 22954-22959 (1997) 82. Sherr, C. J. and Roberts, J. M.: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163 (1995) 83. Harper, J. W. and Elledge, S. J.: Cdk inhibitors in development and cancer. Curr. Opin. Genet. Dev. 6, 56-64 (1996) 84. Tevosian, S. G., Shih, H. H., Mendelson, K. G., Sheppard, K. A., Paulson, K. E. and Yee, A. S.: HBP1 - a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 11, 383-396 (1997) 85. Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A. and Weinberg, R. A.: Effects of an Rb mutation in the mouse. Nature 359, 295-300 (1992) 86. Lee, E. Y., Chang, C. Y., Hu, N., Wang, Y. C., Lai, C. C., Herrup, K., Lee, W. H. and Bradley, A.: Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359, 288-94 (1992) 87. Clarke, A. R., Maandag, E. R., van Roon, M., van der Lugt, N. M., van der Valk, M., Hooper, M. L., Berns, A. and te Riele, H.: Requirement for a functional Rb-1 gene in murine development. Nature 359, 328-30 (1992) 88. Maandag, E. C. R., Van der Valk, M., Vlaar, M., Feltkamp, C., O'Brien, J., Van Roon, M., Van der Lugt, N., Berns, A. and Te Riele, H.: Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO J. 13, 4260-4268 (1994) 89. Williams, B. O., Schmitt, E. M., Remington, L., Bronson, R. T., Albert, D. M., Weinberg, R. A. and Jacks, T.: Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 13, 4251-9 (1994) 90. Lee, M. H., Williams, B. O., Mulligan, G., Mukai, S., Bronson, R. T., Dyson, N., Harlow, E. and Jacks, T.: Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 10, 1621-32 (1996) 91. Ewen, M. E., Xing, Y. G., Lawrence, J. B. and Livingston, D. M.: Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66, 1155-64 (1991) 92. Zhu, L., van den Heuvel, S., Helin, K., Fattaey, A., Ewen, M., Livingston, D., Dyson, N. and Harlow, E.: Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 7, 1111-25 (1993) 93. Li, Y., Graham, C., Lacy, S., Duncan, A. M. and Whyte, P.: The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev. 7, 2366-77 (1993) 94. Hannon, G. J., Demetrick, D. and Beach, D.: Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev. 7, 2378-91 (1993) 95. Mayol, X., Grana, X., Baldi, A., Sang, N., Hu, Q. and Giordano, A.: Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene 8, 2561-6 (1993) 96. Beijersbergen, R. L., Kerkhoven, R. M., Zhu, L., Carlee, L., Voorhoeve, P. M. and Bernards, R.: E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 8, 2680-2690 (1994) 97. Ginsberg, D., Vairo, G., Chittenden, T., Xiao, Z. X., Xu, G., Wydner, K. L., DeCaprio, J. A., Lawrence, J. B. and Livingston, D. M.: E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 8, 2665-2679 (1994) 98. Sardet, C., Vidal, M., Cobrinik, D., Geng, Y., Onufryk, C., Chen, A. and Weinberg, R. A.: E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. USA 92, 2403-2407 (1995) 99. Hijmans, E. M., Voorhoeve, P. M., Beijersbergen, R. L., Van't Veer, L. J. and Bernards, R.: E2F-5, a new E2F family member that interacts with p130 in vivo. Mol. Cell. Biol. 15, 3082-3089 (1995) 100. Helin, K., Lees, J. A., Vidal, M., Dyson, N., Harlow, E. and Fattaey, A.: A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70, 337-50 (1992) 101. Kaelin, W. G. J., Krek, W., Sellers, W. R., DeCaprio, J. A., Ajchenbaum, F., Fuchs, C. S., Chittenden, T., Li, Y., Farnham, P. J., Blanar, M. A., Livingston, D. M. and K., F. E.: Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70, 351-64 (1992) 102. Shan, B., Zhu, X., Chen, P. L., Durfee, T., Yang, Y., Sharp, D. and Lee, W. H.: Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12, 5620-31 (1992) 103. Ivey, H. M., Conroy, R., Huber, H. E., Goodhart, P. J., Oliff, A. and Heimbrook, D. C.: Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol. 13, 7802-12 (1993) 104. Lees, J. A., Saito, M., Vidal, M., Valentine, M., Look, T., Harlow, E., Dyson, N. and Helin, K.: The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 13, 7813-25 (1993) 105. Helin, K., Holm, K., Niebuhr, A., Eiberg, H., Tommerup, N., Hougaard, S., Poulsen, H. S., Spangthomsen, M. and Norgaard, P.: Loss of the Retinoblastoma protein-related p130 protein in Small Cell Lung Carcinoma. Proc. Natl. Acad. Sci. USA 94, 6933-6938 (1997) 106. Stubdal, H., Zalvide, J. and Decaprio, J. A.: Simian Virus 40 Large T antigen alters the phosphorylation state of the Rb-related proteins p130 and p107. J. Virol. 70, 2781-2788 (1996) 107. Stubdal, H., Zalvide, J., Campbell, K. S., Schweitzer, C., Roberts, T. M. and Decaprio, J. A.: Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol. Cell. Biol. 17, 4979-4990 (1997) 108. Zalvide, J. and DeCaprio, J. A.: Role of pRb-related proteins in Simian Virus 40 large-T-antigen-mediated transformation. Mol. Cell. Biol. 15, 5800-5810 (1995) 109. Christensen, J. B. and Imperiale, M. J.: Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen. J. Virol. 69, 3945-3948 (1995) |