[Frontiers in Bioscience 3, d1005-1010, September 15, 1998]
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MOLECULAR EVENTS IN MELANOMA DEVELOPMENT AND PROGRESSION

Friedegund Meier1, Kapaettu Satyamoorthy1, Mark Nesbit1, Mei-Yu Hsu1, Birgit Schittek2, Claus Garbe2, and Meenhard Herlyn1

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 191041, Department of Dermatology, University of Tuebingen, Liebermeisterstr.25, 72076 Tuebingen, Germany2

Received 7/17/98 Accepted 8/10/98

9. REFERENCES

1. Parker, S. L., T. Tong, S. Bolden & P. A. Wingo: Cancer statistics. Cancer Clin 47, 5-27 (1997)

2. Clark, Jr. W. H., D. E. Elder, D. Guerry, IV, M. N. Epstein, M. H. Greene & M. van Horn: A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 15, 1147-1165 (1984)

3. Clark, W. H.: Tumour progression and the nature of cancer. Brit J Cancer 64, 631-644 (1991)

4. Balaban, G., M. Herlyn, D. Guerry, IV, R. Bartolo, H. Koprowski, W. H. Clark, Jr. & P. C. Nowell: Cytogenetics of human malignant melanoma and premalignant lesions. Cancer Genet Cytogenet 11, 429-439 (1984)

5. Balaban, G. B., M. Herlyn, W. H. Clark, Jr. & P. C. Nowell: Karyotypic evolution in human malignant melanoma. Cancer Genet Cytogenet 19, 113-122 (1986)

6. Mancianti, M. L., T. Györfi, I.-M. Shih, I. Valyi-Nagy, G. Levengood, H.-D. Menssen, A. C. Halpern, D. E. Elder & M. Herlyn: Growth regulation of cultured human nevus cells. J Invest Dermatol 100, 281S-287S (1993)

7. Valyi-Nagy, I. T., G. F. Murphy, M. L. Mancianti, D. Whitaker & M. Herlyn: Phenotypes and interactions of human melanocytes and keratinocytes in an epidermal reconstruction model. Lab Invest 62, 314-324 (1990)

8. Valyi-Nagy, I. T., G. Hirka, P. J. Jensen, I.-M. Shih, I. Juhasz & M. Herlyn: Undifferentiated keratinocytes control growth, morphology, and antigen expression of normal melanocytes through cell-cell contact (see comments). Lab Invest 69, 152-159 (1993)

9. Hsu, M.-Y., M. Nesbit, J. L. Meinkoth, Y.-Y. Hsu & M. Herlyn: E-cadherin expression restores the keratinocyte-dependent phenotype in human melanoma cells. Submitted

10. Hsu, M.-Y., M. J. Wheelock, K. R. Johnson & M. Herlyn: Shifts in cadherin profiles between human normal melanocytes and melanomas. J Invest Dermatol Sympos Proc 1, 188-194 (1996)

11. Herlyn, M.: Molecular and cellular biology of melanoma. R.G. Landes Co., Austin, TX (1993)

12. Satyamoorthy, K., E. Dejesus, A. Linnenbach, B. Kraj, D. L. Kornreich, S. Rendle & D. E. Elder & M. Herlyn: Melanoma cell lines from different stages of progression and their biological and molecular analyses. Melanoma Res 7, S35-S42 (1997)

13. Guerry, D., IV, M. Synnestvedt, D. E. Elder & D. Schultz: Lessons from tumor progression. The invasive radial growth phase of melanoma is common, incapable of metastases, and indolent. J Invest Dermatol 100, 342S-345S (1993)

14. Kath, R., U. Rodeck, A. Parmiter, J. Jambrosic & M. Herlyn: Growth factor independence in vitro of primary melanoma cells from advanced but not early or intermediate lesions. Cancer Therapy Control 1, 179-191 (1990)

15. Kath, R., J. A. Jambrosic, L. Holland, U. Rodeck & M. Herlyn: Development of invasive and growth factor-independent cell variants from primary human melanomas. Cancer Res 51, 2205-2211 (1991)

16. Rubinfeld, B., P. Robbins, M. El-Gamil, I. Albert, E. Porfiri & P. Polakis: Stablization of beta-catenin by genetic defects in melanoma cell lines. Science 275, 1790-1792 (1997)

17. Behrens, J., J. P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl & W. Birchmeier: Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382, 638-642 (1996)

18. Shih, I.-M., D. E. Elder, M.-Y. Hsu & M. Herlyn: Regulation of MelCAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes. Am J Pathol 145, 837-845 (1994)

19. Shih, I.-M., D. Speicher, M.-Y. Hsu, E. Levine & M. Herlyn: Melanoma cell-cell interactions are mediated through heterophilic Mel-CAM/ligand adhesion. Cancer Res 57, 3835-3840 (1997)

20. Albelda, S. M., S. P. Mette, D. E. Elder, R. M. Stewart, L. Damjanovich, M. Herlyn & C. A. Buck: Integrin distribution in malignant melanoma: association of the beta3 subunit with tumor progression. Cancer Res 50, 6757-6764 (1990)

21. Hieken, T. J., M. Farolan, S. G. Ronan, A., Shilkaitis, L. Wild & T. K. Das Gupta: Beta3 integrin expression in melanoma predicts subsequent metastasis. J Surg Res 63, 169-173 (1996)

22. Hsu, M.-Y., F. E. Meier, J.-Y. Hsu, P. VanBelle, M. Nesbit, D. G. Elder & M. Herlyn: Expression of E-cadherin suppresses the malignant phenotype in human melanoma. Submitted

23. Van Belle, P., U. Rodeck, I. Nuamah, A. C. Halpern & D. E. Elder: Melanoma-associated expression of transforming growth factor-beta isoforms. Am J Pathol 148, 1887-1894 (1996)

24. Bellone, G., M. Aste-Amezaga, G. Trinchieri & U. Rodeck: Regulation of NK cell functions by TGF-beta 1. J Immunol 155, 1066-1073 (1995)

25. Nesbit, M., E. S. Atillasoy, T. Crombleholme, B. Glatt, R. Elenitsas, R. Beuerman & M. Herlyn: Adenoviral mediated gene transfer of VEGF 121 to human skin results in hemangioma formation. Submitted

26. Nesbit, M., B. Glatt, I.-M. Shih, M.-Y. Hsu, R. Elenitsas, L. P. Bucky & M. Herlyn: Induction of a transformed phenotype of normal human skin fibroblasts by PDGF-B overexpression. Submitted

27. Oka, M., M. Nesbit, K. Satyamoorthy, O. Tomescu, R. Elenitsas, K. Matsushima, M. Ichihashi & M. Herlyn: Metastatic but not primary melanoma cells escape from neutrophil attack induced by adenoviral gene transfer of IL-8. Submitted