[Frontiers in Bioscience 3, d781 -794, August 1, 1998]
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FGF SIGNALING IN SKELETAL DEVELOPMENT

Michael C. Naski and David M. Ornitz

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid Ave., St. Louis, MO 63110

Received12/22/98 Accepted 2/17/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1 FGF receptor alternative splicing
2.2 Glycosaminoglycan interactions
2.3 FGF receptor mutations in human disease
3. Limb Development
3.1 FGF signaling and limb initiation
3.2 FGF receptors and limb development
4. Endochondral ossification
4.1 FGFs and cartilage
4.2 FGF receptors and endochondral ossification
5. Intramembranous bone formation
5.1 FGFs and intramembranous bone formation
5.2 FGF receptors and intramembranous bone formation
6. Conclusion
7. Acknowledgments
8. References
9. Entire manuscript

Key words: FGF Signaling, Receptor Tyrosine Kinase, Intramembranous Ossification, Limb Development, Endochondral Ossification, Skeletal Dysplasia

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