[Frontiers in Bioscience, 3, d436-446, April 16, 1998]
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THE ESSENTIAL ROLE OF INFLAMMATION AND INDUCED GENE EXPRESSION IN THE PATHOGENIC PATHWAY OF ALZHEIMER’S DISEASE

Lars Nilsson1, Jack Rogers2 and Huntington Potter1

Department of Neurobiology1, Harvard Medical School and Division of Hematology, Department of Medicine2, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

Received 3/30/98 Accepted 4/3/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Amyloid-associated proteins
4. Cytokines
5. Epidemiology
6. Pathological chaperones – the accelerator hypothesis
7. Acknowledgements
8. References
9. Entire manuscript

Key words:Alzheimer’s Disease, Alpha1-Antichymotrypsin, Apolipoprotein E, Beta-Amyloid, Chaperone, Cytokine, Gene Expression, Inflammation

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