[Frontiers in Bioscience 3, d961-972, September 1, 1998]
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CAVEAT LECTOR




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PHYSIOLOGIC IMPORTANCE OF PROTEIN PHOSPHATASE INHIBITORS

Carey J. Oliver and Shirish Shenolikar

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710

Received 8/14/98 Accepted 8/20/98

TABLE OF CONTENTS

1.Abstract
2.Introduction
2.1. Introduction to protein serine/threonine phosphatases
2.1.1. Protein phosphatase 1
2.1.2. Protein phosphatase 2A
2.1.3. Protein phosphatase 2B
2.1.4. Other protein serine/threonine phosphatases
3.Protein phosphatase inhibitors
3.1. PP1 inhibitors
3.1.1. Inhibitor-1
3.1.1.1. I-1 and Glycogen Metabolism
3.1.1.2. I-1 and Synaptic Plasticity
3.1.1.3. I-1 and Cell Growth
3.1.1.4. I-1 and Muscle Contraction
3.1.2. DARPP-32
3.1.2.1. DARPP-32 and Na/K-ATPase
3.1.2.2. DARPP-32, Lipogenesis and Lipolysis
3.1.3. Inhibitor-2
3.1.3.1. I-2 and Sperm Motility
3.1.4. NIPP-1
3.1.4.1. NIPP-1 and RNA Metabolism
3.1.5. RIPP-1 3.1.6. CPI17
3.2. PP2A inhibitors
3.2.1. I1PP2A
3.2.2. I2PP2A
3.3. Endogenous PP2B inhibitors
4. Phosphatase inhibitors and human disease
5.Perspectives
6.References
7. Entire manuscript

Key words: Phosphatases, Inhibitors, Hormone Control, Glycogen Metabolism, Long-Term Potentiation