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PubMed
CAVEAT LECTOR
T CELL SIGNALING: EFFECT OF AGE
Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System and Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78284
Received 10/4/98 Accepted 10/12/98
7. REFERENCES
1. M. A. Pahlavani: Immunological aspects of aging. Drugs of Today 23, 611-624 (1987)
2. M. L. Thoman & W. O. Weigle: The Cellular and subcellular bases of immunosenescence. Adv Immunol 46, 221-237 (1987)
3. D. M. Murasko & I. M. Goonewardene: T-Cell function in aging: Mechanisms of decline. Ann Rev Gerontol 10, 71-88 (1990)
4. R. A. Miller: Aging and immune function. Int Rev Cytol 124,187-193 (1991)
5. G. Pawelec, E. Remarque,Y. Barnett, and R. Solana: T cells and aging. Front Biosc 3, 59-99 (1997)
6. M. A. Pahlavani & A. Richardson: The effect of age on the expression of interleukin-2. Mech Ageing Dev 89, 125-154 (1996)
7. E. Cano & L. C. Mahadevan: Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20, 117-122 (1995)
8. J. Wu , J. K.Harrison, P. Dent, K.R. Lynch, M.J. Weber, & T.W. Sturgill: Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. Mol Cell Biol 13, 4539-4548 (1993)
9. K. M. Brumbaugh, B. A. Binstadt, & P.J. Leibson: Signal transduction during NK cell activation: balancing opposing forces. Current Topics in Microbiology & Immunology. 230, 103-22, (1998)
10. T. S. Lewis, P. S. Shapiro, & N. G. Ahn: Signal transduction through MAP kinase cascades. Advances in Cancer Research 74, 49-139, (1998)
11. V. L. Tybulewicz: Analysis of antigen receptor signalling using mouse gene targeting. Curr Opin Cell Biol 10, 195-204, (1998)
12. C. Kung & M. Thomas: Recent advances in lymphocyte signaling and regulation. Front Biosci 2, 206-221 (1997)
13. G. R. Crabtree: Contingent genetic regulatory events in T lymphocyte activation. Science 243, 355-361 (1989)
14. C. A. Janeway & P. Golstein: Lymphocyte activation and effector functions. Editorial overview. The role of cell surface molecules. Curr Opin Immunol 5, 313-323 (1993)
15. Z. Dembic, W. Hass, S. Weiss, J. McCubery, H. Kiefer, & H. Von Boemer: Transfer of specificity by murine 1 and b T cell receptor genes. Nature 320, 232-238 (1986)
16. L. E. Samelson, M. D. Patel, A. M. Weissman, J. B. Harford & R. D. Klausner: Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with T cell antigen receptor. Cell 46, 1983-1090 (1986)
17. A. De La Hera, U. Muller, Sc. Olsson, S. Isaaz & A. Tunnacliffe: Structure of T cell receptor antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex. J Exp Med 173, 7-17 (1991)
18. A. M. Weissman, J. S. Bonifacino, R. D. Klausner, L. E. Samelson & J. J. O'Shea: T cell antigen receptor: structure, assembly and function. Year Immunol 4, 74-93 (1989)
19. A. Weiss: T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell 73, 209-212 (1993)
20. M. Reth: Antigen receptor tail clue. Nature 338, 383-384 (1989)
21. A. M. Wagner, F. Letourneur, A. Hoevloer, T. Brocker, F. Luton & B. Malissen: The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68, 83-95 (1992)
S. C. Ley, A. A. Davies, B. Druker & M. J. Crumpton: The T cell receptor/CD3 complex and CD2 stimulate the tyrosine phosphorylation of indistinguishable patterns of polypeptides in the human T leukemic cell line Jurkat. Eur J Immunol 21, 2203-2209 (1991)
23. R. D. Klausner & L. E. Samelson: T cell antigen receptor activation pathways: the tyrosine kinase connection. Cell 64, 875-878 (1991)
24. L. E. Samelson & R. D. Klausner: Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J Biol Chem 267, 24913-24916 (1993)
M. Iwashima, B. A. Irving, N. S. Van Oers, A. C. Chan & A. Weiss: Sequential interactions of the TCR with two distinct cytoplamic tyrosine kinases. Science 263, 1136-1139 (1994)
26. E. Arpaia, M. Shahar, H. Dadi, A. Cohen & C. M. Roifman: Defective T cell receptor signaling and CD8+ thymic selection in humans lacking ZAP-70 kinase. Cell 76, 947-958 (1994)
27. M. E. Elder, D. Lin, J. Clever, A. C. Chan, T. J. Hope, A. Weiss & T. G. Parslow: Human severe combined immnuodeficiencies are due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264, 1596-1599 (1994)
28. A. C. Chan, T. A. Kadlecek, M. E. Elder, A. H. Filipovich, W. L. Kuo, M. Iwashima, T. G. Parslow & A. Weiss: ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264, 1599-1601 (1994)
29. E. W. Gelfand, K. Weinberg, B. D. Mazer, T. A. Kadlecek, & A. Weiss: Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. J Exp Med 182,1057-1065 (1995)
30.
31. P. L. Stein, H-M. Lee, S. Rich & P. Soriano: pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70, 741-750 (1992)
32. M. W. Appleby, J. A. Gross, M. P. Cooke, S. D. Levin, X. Qian & R. M. Perlmutter: Defective T cell receptor signaling in mice lacking the thymic isoform of p59csk. Cell 70, 751-763 (1992)
33. D. Anderson, C. A. Koch, L. Grey, C. Ellis, M. F. Moran & T. Pawson: Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science 250, 979-982 (1990)
34. Z. Songyang, S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, & R. J. Lechleider: SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767-778 (1993)
35. G. Waksman, D. Kominos, S. C. Robertson, N. Pant, D. Baltimore, R. B. Birge, D. Cowburn, H. Hanafusa, B. J. Mayer, & M. Overduin: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature 358, 646-653 (1992)
36. L. E. Marengere, Z. Songyang, G. D. Gish, M. D. Schaller, J. T. Parsons, M. J. Stern, L. C. Cantley & T. Pawson: SH2 domain specificity and activity modified by a single residue. Nature 369, 502-505 (1994)
37. M. Sieh, J. B. Bolen & A. Weiss: CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J 12, 315-321 (1993)
38. A. Weiss, G. Koretzky, R. Schatzman & T. Radlecek: Functional activation of the T cell antigen receptor induces tyrosine phosphorylation of phololipase C-1. Proc Natl Acad Sci USA 88, 5484-5488 (1991)
39. J. P. Secrist, L. Karnitz & R. Abraham: T cell antigen receptor ligantion induces tyrosine phsphorylation of phospholipase C-1. J Biol Chem 266, 12135-12139 (1991)
Park, H. W. Rho & S. G. Rhee: CD3 stimulation causes phosphorylation of phospholipase C-1 on serine and tyrosine residues in a human T cell line. Proc Natl Acad Sci USA 88, 5453-5456 (1991)
41. M. J. Berridge & R. F. Irvine: Inositol phosphates and cell signaling. Nature 341, 197-205 (1989)
42. J. B. Imboden & J. D. Stobo: Transmembrane signaling by T cell antigen recptor: perturbation of the T3-antigen receptor complex generates inositol phsphates and releases calcium ions from intracellular stores. J Exp Med 161, 446-456 (1985)
43. Motto, M. Musci, S. E. Ross & G. A. Koretzky: Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C-1 activation in T cell. Mol Cell Biol 16, 2823-2829 (1996)
44. N. M. Valiante, J. H. Philips, L. L. Lanier & P. Parham: Killer cell inhibitor recptor recognition of human leukocytes antigen (HLA) class I blocks formation of a pp36/ PLC- signaling complex in human natural killer (NK) cells. J Exp Med 184, 2243-2250 (1996)
45. A. Weiss, J. Imboden, R. Wiskocil & J. Stobo: The role of T3 in the activation of human T cells. J Clin Immunol 4,165-173 (1984)
46. J. Downward, J. D. Graves, P. H. Warne, S. Rayter & D. A. Cantrell: Stimulation of p21ras upon T-cell activation. Nature 346, 719-723 (1990)
47. J. Downward, J. Graves & D. Cantrell: The regulation and function of p21ras in T cells. Immunol Today 13, 89-92 (1992)
48. G. Pelicci, L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nicoletti, F. Grignani, T. Pawson & P. G. Pelicci: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70, 93-104 (1992)
49. M. Rozakis-Adcock, R. Rernley, J. Wade, T. Pawson & D. Bowtell: The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363, 83-85 (1993)
50. L. Buday & J. Downward: Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73, 611-620 (1993)
51. R. Seger & E. G. Krebs: The MAPK signaling cascade. FASEB J 9, 726-735 (1995)
52. M. S. Marshall: Ras target proteins in eukaryotic cells. FASEB J 9, 1311-1318 (1995)
53. J. K. Jackman, D. G. Motto, Q. Sun, M. Tanemoto, C. W. Turck, G. A. Peltz, G. A. Koretzky, & P. R. Findell: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem 270, 7029-7032 (1995)
54. N. Fang, D. G. Motto, S. E. Ross & G. A. Koretzky: Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. J Immunol, 157, 3769-3773 (1996)
55. J. B. Wardenburg, C. Fu, J. K. Jackman, H. Flotow, S. E. Wilkinson, D. H. Williams, R. Johnson, G. Kong, A. C. Chan& P. R. Findell: Phosphorylationof SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T cell receptor function. J Biol Chem 271, 19641-19644 (1996)
56. J. Wu, D. G. Motto, G. A. Koretzky & A. Weiss: Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4, 593-602 (1996)
57. M. Sieh, A. Batzer, J. Schlessinger & A. Weiss: GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol 14, 4435-4442 (1994)
58. L. Buday, S. E. Egan, P. Rodriguez-Viciana, D. Cantrell & J. Downward: A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J Biol Chem 269, 9010-9023 (1994)
59. E. Nel, S. Gutpta, L. Lee, J. A. Ledbetter & S. B. Kanner: Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. J Biol Chem 270, 18428-18436 (1995)
60. X. Huang, Y. Li, K. Tanka, K G. Moore & J. I. Hayashi: Cloning and characterization of Lck, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 92, 11618-11622 (1995)
61. J. A. Donovan, R. L. Wange, W. Y. Langdon & L. E. Samelson: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. Biol Chem 269, 22921-22924 (1994)
62. Motto, S. E. Ross, J. K. Jackman, Q. Sun, A. L. Olson, F. R. Findell, & G. A. Koretzky: In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase. J Biol Chem 269, 21608-21613 (1994)
63. T. Fukazawa, K. A. Reedquist, G. Panchamoorthy, S. Soltoff, T. Trub, B. Druker, L. Cantley, S. E. Shoelson & H. Band: T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. J Biol Chem 270, 20177-20182 (1995)
64. H. Meisner, B. R. Conway, D. Hartley & M. P. Czech: Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells. Mol Cell Biol 15, 3571-3578 (1995)
65. C. Gulbins, K. M. Coggeshall, G. Baier, S. Katzaw, P. Burn & A. Altman: Tyrosine kinase stimulated guanine nucleotide exchange activity of vav in T cell activation. Science 260, 822-825 (1993)
66. J. M. Adams, H. Houston, J. Allen, T. Lints & R. Harvey: The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. Oncogene 7, 611-618 (1992)
67. A. Tarakhovsky, M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky , V. L. Tybulewicz: Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374, 467-470 (1995)
68. R. Zhang, L. Davidson, S. H. Orkin, & W. Swat: Defective signaling through the T- and B- cells antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374, 470-473 (1995).
K. D. Fischer, A. Zmuidzinas, S. Gardner, M. Barbacid, A. Bernstein, & C. Guidos: Defective T cell receptor signaling and positive selection on Vav-deficient CD4+ CD8+ thymocytes. Nature 374, 474-477 (1995)
70. M. Turner M, P. J. Mee, A. E. Walters, M. E. Quinn, A. L. Mellor, R. Zamoyska, & V. L. Tybulewicz: A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes Immunity 7, 451-460 (1997)
71. M. Izquierdo, S.J. Leevers, C. J. Marshall & D. A. Cantrell: p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J Exp Med 178, 1199-1208 (1993)
72. M. Izquierdo, S. J. Leevers, C. J. Marshall, & D. Cantrell: p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J Exp Med 178, 1199-1208 (1993)
73. C. E. Whitehurst, T. G. Boulton, M. H. Cobb & T. D. Geppert: Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. J Immunol 148, 3230-3237 (1992)
74. B. J. Pulverer, J. M. Kyriakis, J. Avruch, E. Nikolakaki & J. R. Woodgett: Phosphorylation of c-jun mediated by MAP kinases. Nature 353, 670-674 (1991)
75. R. Marais, J. Wynne & R. Treisman: The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73, 381-393 (1993)
76. S. J. Leevers , C. J. Marshall: Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO 11, 569-574 (1992)
O. Sozeri, K. Vollmer, M. Liyanage, D. Frith, G. Kour, E.G. Mark, S. Stabel: Activation of the c-Raf protein kinase by protein kinase C phosphorylation. Oncogene 7, 2259-2262 (1992)
78. M. L. Samuels, M. J. Weber, J. M. Bishop & M. McMahon: Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol 13, 6241-6252 (1993)
79. M. Minden: Growth factor requirements for normal and leukemic cells. Semin Hematol 32, 162-182 (1995)
80. R. J. Davis: MAPKs: new JNK expands the group. Trends Biochem Sci, 19, 470-473 (1994)
81. H. Nishina, M. Bachmann, A. J. Oliveira-dos-Santos, I. Kozieradzki, K.D. Fischer: Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med 186:941-953 (1997)
82. G. A. Koretzky: Role of the CD45 tyrosine phosphatase in signal transduction in the immune system. FASEB J 7, 420-426 (1993)
83. L.B. Justement, V. K. Brown & J. Lin: Regulation of B-cell activation by CD45: a question of mechanism. Immunol Today 15, 399-406 (1994)
84. S. A. Berger, T. W. Mak & C. J. Paige: Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells. J Exp Med 180, 471-476 (1994)
85. L. R. Hall, M. Streuli, S. F. Schlossman & H. Saito: Complete exon-intron organization of the human leukocyte common antigen (CD45) gene. J Immunol 141, 2781-2787 (1988)
86. M. L. Thomas: The regulation of B- and T-lymphocyte activation by the transmembrane protein tyrosine phosphatase CD45. Curr Opin Cell Biol 6, 247-252 (1994)
87. K. Kishihara, J. Penninger, V. A. Wallace et al.: Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice. Cell 74, 143-156 (1993)
88. K. F. Byth, L. A. Conroy, S. Howlett, A. J. H. Smith, J. May, D. R. Alexander & N. Holmes: CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+ CD8+ thymocytes and in B cell maturation. J Exp Med 183, 1707-1718 (1996)
89. B. G. Neel: Role of phosphatases in lymphocyte activation. Curr Opin Immunol 9, 405-420 (1979)
90. J. D. Stone, L. A. Conroy, K. F. Byth, R. A. Hederer, S. Howlett, Y. Takemoto, N. Holmes, & D. R. Alexander: Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70. Immunol 158, 5773-5782 (1997)
91. M. L. Thomas: Positive and negative regulation of leukocyte activation by protein tyrosine phosphatases. Semin Immunol 7, 279-288 (1995)
92. A. Weiss & D. R. Littman: Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274 (1994)
93. U. Lorenz, K. S. Ravichandran, S. J. Burakoff & B. G. Neel: Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness. Proc Natl Acad Sci U S A 93, 9624-9629 (1996)
94. L. D. Shultz, P. A. Schweitzer, T. V. Rajan, T. Yi, J. N. Ihle, R. J. Matthews, M. L. homas & D. R. Beier: Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73, 1445-1454 (1993)
95. T. Yi, A. AL. Mui, G. Krystal & J. H. Ihle: Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol Cell Biol 13, 7577-7586 (1993)
96. M. David, H. E. Chen, S. Goelz, A. C. Larner & B. G. Neel: Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol 15, 7050-7058 (1995)
97. U. Klingmuller, U. Lorenz, L. C. Cantley, B. G. Neel & H. F. Lodish: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80, 729-738 (1995)
98. H. E. Chen, S. Chang, T. Trub & B. G. T, Neel: Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol Cell Biol 16, 3685-3697 (1996)
99. D. R. Plas, R. Johnson, J. T. Pingel, R. J. Matthews, M. Dalton, G. Roy, A. C. Chan & M. L. Thomas: Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272, 1173-1176 (1996)
100. K. Mizuno, T. Katagiri, K. Hasegawa, M. Ogimoto & H. Yakura: Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. J Exp Med 184, 457-463 (1996)
101. M. R. Kuhne, T. Pawson, G. E. Lienhard & G. S. Feng: The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem 268, 11479-11481 (1993)
102. W. Li, R. Nishimura, A. Kashishian, A. G. Batzer, W. J. Kim, J. A. Cooper & J. A. Schlessinger: A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14, 509-517 (1994)
103. T. Tauchi, G. S. Feng, R. Shen, M. Hoatlin, G. C. Bagby, D. Kabat, L. Lu & H. E. Broxmeyer: Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem 270, 5631-5635 (1995)
104. L. E. Marengere, P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng & T. W. Mak: Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272, 1170-1173 (1996)
105. E. A. Tivol, F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone & A. H. Sharpe: Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995)
106. M. F. Krummel & J. P. Allison: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 182, 459-465 (1995)
107. P. Waterhouse, J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser & T. W. Mak: Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995)
108. K. S. Ravichandran, K. K. Lee, Z. Songyang, L. C. Cantley, P. Burn & S. J. Burakoff. Interaction of Shc with the chain of the T cell receptor upon T cell activation. Science 262, 902-905 (1993)
109. C. T. Baldari, G. Pelicci, M. M. Di Somma, E. Milia, S. Giuli, P. G. Pelicci & J. L. Telford: Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein. Oncogene 10, 1141-1147 (1995)
J. Wu, L.F. Lau, & T. W. Sturgill: Rapid deactivation of MAP kinase in PC12 cells occurs independently of induction of phosphatase MKP-1. FEBS Lett 353, 9-12 (1994)
111. H. Sun, C. H. Charles, L. F. Lau, N. K. Tonks: MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:487-493 (1993)
112. P. S. Shapiro & N .G. Ahn: Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1). J Biol Chem 273, 1788-1793 (1998)
113 . J. J. Proust, C. R. Filburn, S. A. Harrison, M. A. Buchholz & A. A. Nordin: Age-related defect in signal transduction during lectin activation of murine T lymphocytes. J Immunol 139, 1472-1478 (1987)
114. R. A. Miller, B. Jacobson, G. Weil & E. R. Simons: Diminished calcium influx in lectin-stimulated T cells from old mice. J Cell Physiol 132, 337-342 (1987)
115 . A. Lerner, B. Jacobson & R. A. Miller: Cyclic AMP concentrations modulate both calcium flux and hydrolysis of phosphatidylinositol phosphates in mouse T lymphocytes. J Immunol 140, 936-940 (1988)
116. L. Nagelkerken & A. Hertogh-Huijbregts: The acquisition of a memory phenotype by murine CD4+ T cells is accompanied by a loss in their capacity to increase intracellular calcium. Dev Immunol 3, 25-34 (1992)
117. A. Grossmann, J. A. Ledbetter & P. S. Rabinovitch: Aging-related deficiency in intracellular calcium response to anti-CD3 or concanavalin A in murine T-cell subsets. J Gerontol 45, B81-B86 (1990)
118. B. Philosophe & R. A. Miller: Diminished calcium signal generation in subsets of T lymphocytes that predominate in old mice. J Gerontol 45, B87-B93 (1990)
119. A. Grossmann, L. Maggio-Price, J. C. Jinneman & P. S. Rabinovitch: Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs. Cell Immunol 135 118-131 (1991)
120. Q. Ran, D. Li, & Y. Zhen: Changes of proto-oncogene expression and cytosolic free calcium in activated T-lymphocytes of aged mice. Chung Hua I Hsueh Tsa Chih 75, 466-469 (1995)
121. M. Utsuyama, A. Wakikawa, T. Tamura, H. Nariuchi & K. Hirokawa: Impairment of signal transduction in T cells from old mice. Mech Ageing Dev 93, 131-144 (1997)
122. T. C. Fong & T. Makinodan: Preferential enhancement by 2-mercaptoethanol of IL-2 responsiveness of T blast cells from old over young mice is associated with potentiated protein kinase C translocation. Immunol Lett 20, 149-154 (1989)
123. J. Shi & R. A. Miller: Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice. J Gerontol 47, B147-B153 (1992)
124. J. Shi & R. A. Miller: Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets. Effect of age. J Immunol 151, 730-739 (1993)
125. A. Grossmann, P. S. Rabinovitch, T. J. Kavanagh, J. C. Jinneman, L. K. Gilliland, J. A. Ledbetter & S. B. Kanner: Activation of murine T-cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with aging. J Gerontol 50, B205-B212 (1995)
126. G. G.Garcia & R. A. Miller: Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age. Cell Immunol 175, 51-57 (1997)
127. J. Ghosh & R. A. Miller: Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: differential effects of aging. Mech Ageing Dev 80, 171-187 (1995)
128. G. Gorgas, E. R. Butch, K. L. Guan & R. A. Miller: Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice. Mech Ageing Dev 94, 71-83 (1997)
129. R. A. Miller, G. Garcia, C, J. Kirk, & J. M. Witkowski: Early activation defect in T lymphocytes from aged mice. Immunol Rev 160, 79-90 (1997).
130. M. A. Pahlavani, M. D. Harris, & A. Richardson: Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats. Cell Immunol 185, 39-48 (1998)
131. A. Grossmann, P.S. Rabinovitch, M. A. Lane, J. C. Jinneman, D, K. Ingram, N. S. Wolf, R. G. Cutler & G. S. Roth: Influence of age, sex, and dietary restriction on intracellular free calcium responses of CD4+ lymphocytes in rhesus monkeys (Macaca mulatta). J Cell Physiol 162, 298-303 (1995)
132. G. Lustyik & J. J. O’Leary: Aging and the mobilization of intracellular calcium by phytohemagglutinin in human T cells. J Gerontol 44, B30-B36 (1989)
133. A. Grossmann, J. A. Ledbetter & P. S. Rabinovitch: Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subset. Exp Cell Res 180, 367-382 (1989)
134. B. Kennes, C. Hubert, D. Brohee & P. Neve: Early biochemical events associated with lymphocyte activation in aging. I. Evidence that Ca2+ dependent processes induced by PHA are impaired. Immunology 42, 119-126 (1981)
135. J. J. O'Shea, D. W. McVicar, T. L. Bailey, C. Burns, & M. J. Smyth: Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc Natl Acad Sci U S A 89, 10306-10310 (1992)
R. Di Pietro, R. A. Rana, A. Sciscio, S. Marmiroli, A. M. Billi, A. Cataldi & L. Cocco: Age-related events in human active T lymphocytes: changes in the phosphoinositidase C activity. Biochem Biophys Res Commun 194, 566-570 (1993)
137. R. L. Whisler, Y. G. Newhouse, I. S. Grants, K. V. Hackshaw: Differential expression of the alpha- and beta-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults. Mech Ageing Dev 77, 197-211 (1995)
138. R. A. Quadri, O. Plastre, M. A. Phelouzat, A. Arbogast & J. J. Proust: Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor. Mech Ageing Dev 88,125-138 (1996)
139. R. L. Whisler & I. S. Grants: Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells. Mech Ageing Dev 71, 31-46 (1993)
140. R. L. Whisler, S. E. Bagenstose, Y. G. Newhouse & K. W. Carle: Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex. Mech Ageing Dev 98, 57-73 (1997)
141. R. L. Whisler, Y. G. Newhouse & S. E. BagenstoseL Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex. Cell Immunol 168, 201-210 (1996)
142. B. Chakravarti, D. N. Chakravrti, J. Devecis, B. Seshi, & G. N. Abraham: Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70. Mech Ageing Dev 194, 41-58, (1998)
143. L. Beiqing, K. W. Carle, & R. L. Whisler: Reduction in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals. Cell Immunol 182, 79-88, (1997)
144. C. W. Tinkle, D. lipshitz, & U. Ponnappan: Decreased association of p56lck with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging. Cell Immunol 186, 154-160, (1998)