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T CELL SIGNALING: EFFECT OF AGE
Mohammad A. Pahlavani
Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System and Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78284
Received 10/4/98 Accepted 10/12/98
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
3. TCR-mediated signal transduction: General Features
- 3.1 Protein tyrosine phosphorylation
3.2 TCR-mediated activation of second messengers
3.3 TCR-mediated Ras activation
3.4 Signaling through MAPK/ERK pathway
3.5 Role of protein tyrosine phosphatases in T cell signaling
- 4. Age-related changes in signal transduction in T cell
- 4.1 Calcium signaling and second messenger generation
4.2 Protein tyrosine phosphorylation and Ras/MAPK activation
- 5. Concluding Remarks
- 6. Acknowledgements
- 7. References
- 8. Entire manuscript
Key words: Signal Transduction, T cell, TCR, MAPK, Ras, Aging
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