[Frontiers in Bioscience, d701-718, July 20, 1998]
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EXCITATORY AMINO ACID NEUROTRANSMISSION. PATHWAYS FOR METABOLISM, STORAGE AND REUPTAKE OF GLUTAMATE IN BRAIN

Monica Palmada and Josep Joan Centelles

Departament de Bioquímica i Biologia Molecular, Facultat de Química, Universitat de Barcelona, Martí i Franquès, 1, 08028-Barcelona, Spain

Received 5/7/98 Accepted 5/23/98

7. REFERENCES

1. Hoop B., Masjedi M.-R., Shih V.E. & Kazemi H.: Brain glutamate metabolism during hypoxia and peripheral chemodenervation. J. Appl. Physiol. 69, 147-154 (1990)

2. Housley G.D. & Sinclair J.D.: Localization by kainic acid lesions of neurones transmitting the carotid chemoreceptor stimulus for respiration in rat. J. Physiol. Lond., 406, 99-114 (1988)

3. Oldendorf W.H.: Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am J Physiol. 221(6), 1629-1639 (1971)

4. Oldendorf W.H. & Szabo J.: Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am J Physiol. 230(1), 94-98 (1976)

5. Pratt O.E.: The transport of metabolizable substances into the living brain. Adv Exp Med Biol. 69, 55-75 (1976)

6. Clarke D.D., Ronan E.J., Dicker E. & Tirri L.: Ethanol and its relation to amino acid metabolism in brain. In Metabolic Compartmentation and Neurotransmission. Eds: Berl S., Clarke D.D., Schneider D. Plenum Press, New York. 449-460 (1975)

7. Balazs R., Machiyama Y., Hammond B.J., Julian T. & Richter D.: The operation of the g -aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro. Biochem. J. 116, 445-467 (1970)

8. Machiyama Y., Balazs R., Hammond B.J., Julian T. & Richer D.: The metabolism of GABA and glucose in potassium stimulated brain tissue in vitro. Biochem. J., 116, 469-482 (1970)

9. Norenberg M.D. & Martínez-Hernández A.: Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res., 161, 303-310 (1979)

10. Berl S., Lajtha A. & Waelsch H.: Amino acid and protein metabolism. VI. Cerebral compartments of glutamic acid metabolism. J. Neurochem. 7, 186-197 (1961)

11. van den Berg C.J., Matheson D.F., Ronda G., Reijnierse G.L.A., Blokhuis G.G.D., Kroon M.C., Clarke D.D. & Garfinkel D.: A model of glutamate metabolism in brain: a biochemical analysis of a heterogenous structure. In Metabolic Compartmentation and Neurotransmission. Eds: Berl S., Clarke D.D., Schneider D. Plenum Press, New York. 709-723 (1975)

12. Tanabe Y., Masu M., Ishii T., Shigemoto R. & Nakanishi S.: A family of metabotropic glutamate receptors. Neuron. 8(1), 169-179 (1992)

13. Watkins J.C. & Collingridge G.L.: In The NMDA receptor. Oxford: Oxford Univ. Press. (1989)

14;. Daw N.W., Stein P.S.G. & Fox K.: The role of NMDA receptors in information processing. Annu. Rev. Neurosci. 16, 207-222 (1993)

15. Thomas RJ: Excitatory amino acids in health and disease. Journal of the American Geriatrics Society 43(11), 1279-1289 (1995)

16. Muller W.E., Mutschler E. & Riederer P.: Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia. Pharmacopsychiatry 28(4), 113-124 (1995)

17. Coyle J.T: An animal model for Huntington's disease. Biological Psychiatry 14(2),251-276 (1979)

18. McDonald J.W. &Johnston M.V.: Pharmacology of N-methyl-D-aspartate-induced brain injury in an in vivo perinatal rat model. Synapse. 6(2), 179-188 (1990)

19. Flatman J.A., Schwindt P.C. & Crill W.E.: The induction and modification of voltage-sensitive responses in cat neocortical neurons by N-methyl-D-aspartate. Brain Res. 363, 62-77 (1986)

20. Nowak L., Bregetowski P., Ascher P., Herbet A. & Prochiantz A.: Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307, 462-465 (1984)

21. Mayer M.L., McDermott A.B., Westbrook G.L., Smith S.J. & Barker J.L.: Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III. J. Neurosci. 7, 3230-3244 (1987)

22. Watanabe M.: Dynamic regulation of the NMDA receptor channel subunits in the central nervous system and their involvement in synaptic plasticity and development. Kaibogaku Zasshi - Journal of Anatomy 71(5),517-522 (1996)

23. Mayer M.L. & Westbrook G.L.: The physiology of excitatory amino acids in the vertebrate central nervous system. Prog. Neurobiol. 28, 197-276 (1987)

24. Murphy S.N., Thayer S.A. & Miller R.J.: The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons. J. Neurosci. 7, 4145-4158 (1987)

25. Iino M., Ozawa S. & Tsuzuki K.: Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. J. Physiol. (London) 424, 151-165 (1990)

26. Gilbertson T.A., Scobey R. & Wilson M.: Permeation of calcium ions through non-NMDA glutamate channels in retinal bipolar cells. Science 251, 1613-1615 (1991)

27. Sugiyama H., Ito I. & Hirono C.: A new type of glutamate receptor linked to inositol phospholipid metabolism. Nature 325, 531-533 (1987)

28. Schoepp D., Bockaert J. & Sladeczek F.: Pharmacological and functional characteristics of metabotropic excitatory amino acid receptor. Trends Pharmacol. Sci. 11, 508-515 (1990)

29. Sugiyama H., Ito I. & Watanabe S.: Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA. Neuron 3, 129-132 (1989)

30. Batchelor A.M, Madge D.J. & Garthwaite J.: Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices. Neuroscience 63(4), 911-915 (1994)

31. Fei Y.J, Kanai Y., Nussberger S., Ganapathy V., Leibach F.H., Romero M.F., Singh S.K., Boron W.F. & Hediger M.A.: Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368, 563-566 (1994)

32. Pines G, Danbolt N.C., Bjoras M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E. & Kanner B.I.: Cloning and expression of a rat brain L-glutamate transporter. Nature 360, 464-467 (1992)

33. Storck T, Schulte S., Hofmann K. & Stoffel W.: Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proceedings of the National Academy of Sciences of the United States of America 89(22),10955-10959 (1992)

34. Fairman W.A, Vandenberg R.J., Arriza J.L., Kavanaugh M.P. & Amara S.G.: An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375, 599-603 (1995)

35. Arriza J.L., Eliasof S., Kavanaugh M.P. & Amara S.G.: Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proceedings of the National Academy of Sciences of the United States of America 94(8),4155-4160 (1997)

36. Tolner B., Poolman B., Wallace B. & Konings W.N.: Revised nucleotide sequence of the gLTP gene which encodes the proton glutamate aspartate transport protein of Escherichia-Coli k-12. Journal of Bacteriology 174, 2391-2393 (1992)

37. Jiang J., Gu B., Albright L.M. & Nixon B.T.: Conservation between coding and regulatory elements of Rhizobium-Meliloti and Rhizobium-leguminosarum DCT genes. Journal of Bacteriology 171 (10), 5244-5253 (1989)

38. Deguchi Y., Yamato I. & Anraku Y.: Nucleotide sequence of gltS, the Na+/glutamate symport carrier gene of Escherichia coli B. Journal of Biological Chemistry 265(35), 21704-21708 (1990)

39. Kalman M., Gentry D.R. & Cashel M.: Characterization of the Escherichia-Coli k-12 GLT-S glutamate permease gene. Molecular & General Genetics 225 (3), 379-386 (1991)

40. Guastella J., Nelson N., Nelson H., Czyzyk L., Keynan S., Miedel M.C., Davidson N., Lester H.A. & Kanner B.I.: Cloning and expression of a rat brain GABA transporter. Science 249, 1303-1306 (1990)

41. Shimada S., Kitayama S., Lin C.L., Patel A., Nanthakumar E., Gregor P., Kuhar M. & Uhl G.: Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 254, 576-578 (1991)

42. Kloeckner U., Storck T., Conradt M. & Stoffel W.: Electrogenic L glutamate uptake in Xenopus-laevis oocytes expressing a rat brain L glutamate-L-aspartate transporter GLAST-1. Journal of Biological Chemistry 268 (20), 14594-14596 (1993)

43. Balcar V.J. & Johnston G.A.R.: The structural specificity of the high affinity uptake of L-glutamate and L-aspartate by rat brain slices. Journal of Neurochemistry 19, 2657-2666 (1972)

44. Mc Bean G.J. & Roberts P.J.: Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. Journal of Neurochemistry 44, 247-254 (1985)

45. Palmer A.M., Procter A.W., Stratmann G.C. & Bowen D.M.: Excitatory amino-acid-releasing and cholinergic neurons in Alzheimer´s disease. Neuroscience Letters 66 (2),199-204 (1986)

46. Kanner B.I.: Glutamate transporters from brain: a novel neurotransmitter transporter family. FEBS Lett. 325, 95-99 (1993)

47. Keinanen K, Wisden W., Sommer B., Werner P., Herb A., Verdoorn T.A., Sakmann B. & Seeburg P.H.: A family of AMPA-selective glutamate receptors. Science 249, 556-560 (1990)

48. Lehre K.P., Levy L.M., Ottersen O.P., Storm-Mathisen J. & Danbolt N.C.: Differential expression of two glutamate transporters in rat brain: quantitative and immunocytochemical observations. J. Neurosci. 15:1835-1853 (1995)

49. Kanner B.I & Schuldiner S.: Mechanism of transort and storage of neurotransmitters. Critical Reviews in Biochemistry 22 (1), 1-38 (1987)

50. Nicholls D. & Attwell D.: The release and uptake of excitatory amino acids. Trends in Pharmacological Sciences 11 (11), 462-468 (1990)

51. Pines G. & Kanner B.I.: Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brain. Biochemistry 29 (5),11209-11214 (1990)

52. Balcar V.J. & Johnston G.A.R.: Glutamate uptake by brain slices and its relation to the depolarization of neurones by acidic amino acids. Journal of Neurobiology 3, 295-301 (1972)

53. Kanner B.I. & Sharon I.: Active transport of L-glutamate by membrane vesicles isolated from rat brain. Biochemistry 17, 3949-3953 (1978)

54. Danbolt N.C., Pines G. & Kanner B.I.: Purification and reconstitution of the sodium and potassium-coupled glutamate transport glycoprotein from rat brain. Biochemistry 29 (28), 6734-6740 (1990)

55.Bridges R.J., Stanley M.S., Anderson M.W., Cotman C.W. & Chamberlin A.R.: Conformationally defined neurotransmitter analogues selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. Journal of Medicinal Chemistry 34 (2), 717-725 (1991)

56. Nagy D., Kato T. & Kushner P.D.: Reactive astrocytes are widesprad in the cortical gray matter of amyotrophic lateral sclerosis. J. Neurosci. Res. 38, 336-347 (1994)

57. Bristol, L.A. & Rothstein, J.D.: Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex. Ann. Neurol. 39:676-679 (1996)

58. Kanai Y. & Hediger M.A.: Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360, 467-471 (1992)

59. Blakely R.D., Berson H.E., Fremeau R.T. Jr., Caron M.G., Peek M.M., Prince H.K. & Bradley C.C.: Cloning and expression of a functional serotonin transporter from rat brain. Nature 354, 66-70 (1991)

60. Bouvier M., Szatkowski M., Amato A. & Attwell D.: The glial cell glutamate uptake carrier countertransports pH-changing anions. Nature 360, 471-474 (1992)

61. Zaczek R., Arlis S., Markl A., Murphy T., Drucker H. & Coyle J.T.: Characteristics of chloride-dependent incorporation of glutamate into brain membranes argue against a receptor binding site. Neuropharmacology 20 (4), 281-288 (1987)

62. Pin J.P., Bockaert J. & Recasens M.: The calcium-chloride- dependent L-[3H]glutamate binding: a new receptor or a particular transport process?. FEBS Letters 175, 31-36 (1984)

63. Sheng M.: PDZs and receptor/channel clustering: rounding up the latest suspects. Neuron 17(4), 759-67 (1996)

64. Kanner B.I. & Schuldiner S.: Mechanism of transport and storage of neurotransmitters. CRC Crit. Rev. Biochem. 22, 1-38 (1987)

65. Johnson R.: Accumulation of biological amines in chromaffin granules: a model for hormone and neurotransmitter transport. Physiol. Rev. 68, 232-307 (1988)

66. Burger P.M, Mehl E., Cameron P.L., Maycox P.R., Baumert M., Lottspeich F., DeCamilli P. & Jahn R.: Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate. Neuron 3:715-720 (1989)

67. Naito S. & Ueda T.: Adenosine triphosphatase-dependent uptake of glutamate into protein I-associated synaptic vesicles. J. Biol. Chem. 258, 696-699 (1983)

68. Hartiger J. & Jahn R.: An anion binding site that regulates the glutamate transporter of synaptic vesicles. J. Biol. Chem. 268(31), 23122-23127 (1993)

69. Moriyama Y. & Yamamoto A.: Microvesicles isolated from bovine pineal gland specifically accumulate L-glutamate. FEBS Lett. 367, 233-236 (1995)

70. Maycox P.R., Deckwerth T., Hell J.W. & Jahn R.: Glutamate uptake by brain synaptic vesicles. J. Biol. Chem. 263, 15423-15428 (1988)

71. Naito S. & Ueda T.: Characterization of glutamate uptake into synaptic vesicles. J. Neurochem. 44, 99-109 (1985)

72. Moriyama Y. & Yamamoto A.: Vesicular L-glutamate transporter in microvesicles from bovine pineal glands. Driving force, mechanism of chloride anion activation, and substrate specificity. J. Biol. Chem 270(38), 22314-22320 (1995)

73. Sokoloff L., Takahashi S., Gotoh J., Driscoll B.F. & Law M.J.: Contribution of astroglia to functionally activated energy metabolism. Dev. Neurosci., 18(5-6), 344-52 (1996)

74. McLennan H.: The autoradiographic localization of L-[3H] glutamate in rat brain tissue. Brain Res. 115, 139-144 (1976)

75. Hertz L. & Schousboe A.: Role of astrocytes in compartmentation of amino acid and energy metabolism. In Astrocytes. Eds: Federoff S., Vernadakis A. Academic Press, New York. Vol. 2, 179-208 (1986)

76. Hertz L. & Schousboe A.: Metabolism of glutamate and glutamine in neurons and astrocytes in primary cultures. In Glutamine and glutamate in mammals. Eds: Kvamme E. CRC Press, Boca Raton, Fla. Vol. 2, 39-55 (1988)

77. Hertz L., Yu A.C.H. & Schousboe A.: Uptake and metabolism of malate in cultured neurons and astrocytes. J. Neurosci. Res. 33, 289-396 (1992)

78. Hertz L., Peng L., Westergaard N., Yudkoff M. & Schousboe A.: Neuronal-astrocytes interactions in metabolism of transmitter amino acids of the glutamate family. In Alfred Benzon Symposium. No. 32: Drug research related to neuroactive amino acids. (Schousboe A. & Diemer N. eds.) Munksgaard, Copenhagen. (1992)

79. Yu A.C.H. & Hertz L.: Metabolic sources of energy in astrocytes. In Glutamine, glutamate and GABA in the central nervous system. (Hertz L., Kvamme E., McGeer E.G. & Schousboe A. eds.) Alan R. Liss, New York. (1983)

80. Tildon J.T. & Roeder L.M.: Glutamine oxidation by dissociated cells and homogenates of rat brain: kinetics and inhibitor studies. J. Neurochem. 42, 26-35 (1984)

81. Solokoff L.: The brain as a chemical machine. In Neuronal-astrocytic interactions: their implications in normal and pathological brain function (Yu A., Hertz L., Norenberg M.D., Sykova E. & Waxman S. eds.) Prog. Brain Res. 94 (1992)

82. Erecinska M., Nelson D. & Chance B.: Depolarization induced changes in cellular energy production. Proc. Natl. Acad. Sci. USA 88, 7600-7604 (1991)

83. Code W.E., White H.S. & Hertz L.: The effect of midazolam on calcium signaling in astrocytes. Ann. N.Y. Acad. Sci. 625, 430-432 (1991)

84. Tate S.S., Leu F.-Y. & Meister A.: Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate. J. Biol. Chem., 247 (17), 5312-5321 (1972)

85. Woolfolk C.A., Shapiro B. & Stadtman E.R.: Regulation of glutamine synthetase. I. Purification and properties of glutamine synthetase from Escherichia coli. Arch. Bioch. Biophys., 116, 117-192 (1966)

86. Deuel T.F., Louie M. & Lerner A.: Glutamine synthetase from rat liver. Purification, properties, and preparation of specific antisera. J. Biol. Chem., 253 (17), 6111-6118 (1978)

87. Wilk S., Meister A., Haschemeyer R.H.: Dissociation of native octameric brain glutamine synthetase to a tetramer by treatment with N-acetylimidazole. Biochemistry 9(10), 2039-2043 (1970)

88. Berl S.: Glutamine synthetase: determination of its distribution in brain development. Biochemistry 5, 916-922 (1966)

89. Cooper A.J.W., Veraga F. & Duffy T.E.: Cerebral glutamide synthetase. In Glutamine, glutamate and GABA in the central nervous system. Eds: Hertz L., Kvamme E., McGeer E.G., Schousboe A. New York: Liss. 77-93 (1983)

90. Weyne J., VanLeuven F., Kazemi H. and Leusen I. (1978) Selected brain amino acids and ammonium during chronic hypercapnia in conscious rats. J. Appl. Physiol. 44, 333-339 (1978)

91. Tatibana M. & Ito K.: Carbamyl phosphate synthetase of the hematopoietic mouse spleen and the control of pyrimidine biosynthesis. Biochem-Biophys-Res-Commun. 26(2), 221-227 (1967)

92. Hogstad S., Svenneby G., Torgner I. Aa., Kvamme E., Hertz L. & Schousboe A.: Glutaminase in neurons and astrocytes cultured from mouse brain: kinetic properties and effect of phosphate, glutamate and ammonia. Neurochem. Res. 13(4), 383-388 (1988)

93. Ward H.K. & Bradford H.F.: Relative activities of glutamine synthetase and glutaminase in mammalian synaptosomes. J. Neurochem., 33, 339-342 (1979)

94. Kaneko T., Urade Y., Watanabe Y. & Mizuno N.: Production, characterization, and immunohistochemical application of monoclonal antibodies to glutaminase purified from rat brain. J. Neurosci. 7, 302-309 (1987)

95. Nimmo G.A. & Tipton K.F.: The distribution of soluble and membrane-bound forms of glutaminase in pig brain. J. Neurochem., 33, 1089-1094 (1979)

96. Nimmo G.A. & Tipton K.F.: Purification of soluble glutaminase from pig brain. Biochem. Pharmacol. 29, 359-367 (1980)

97. Svenneby G., Torgner I.A. & Kvamme E.: Purification of phosphate-dependent pig brain glutaminase. J. Neurochem. 20, 1217-1224 (1973)

98. Kvamme E., Svenneby G. & Tveit B.: In Molecular Basis of some aspects of mental activity. Eds: Walaas O. Academic Press, New York 211-219 (1966)

99. Curthoys N.P., Kuhlenschmidt T., Godfrey S.S. & Weiss R.F.: Phosphate-dependent glutaminase from rat kidney. Cause of increased activity in response to acidosis and identity with glutaminase from other tissues. Arch. Biochem. Biophys. 172(1), 162-167 (1976)

100. Horowitz M.L. & Knox W.E.: A phosphate activated glutaminase in rat liver different from that in kidney and other tissues. Enzymol. Biol. Clin. Basel. 9(4), 241-255 (1968)

101. Nimmo G.A. & Tipton K.F.: Kinetic comparisons between soluble and membrane-bound glutaminase preparations from pig brain. FEBS Letters, 57-64 (1981)

102. Svenneby G.: Time and temperature dependent activation of pig brain glutaminase. J. Neurochem. 19, 165-174 (1972)

103. Kvamme E. & Torgner I. Aa.: The effect of acetyl-coenzyme A on phosphate-activated glutaminase from pig kidney and brain. Biochem. J. 137, 525-530 (1974)

104. Collins R.M. Jr., Zielke H.R. & Woody R.C.: Valproate increases glutaminase and decreases glutamine synthetase activities in primary cultures of rat brain astrocytes. J. Neurochem., 62, 1137-1143 (1994)

105. Palmada M. & Centelles J.J.: The effect of pH on glutamate dehydrogenase from bovine brain mitochondria. Submitted (1998)

106. Grisolia S., Quijada C.L. & Fernandez M.: Glutamate dehydrogenase from yeast and from animal tissues. Biochim. Biophys. Acta, 81, 61 (1964)

107. Colon A., Plaitakis A., Perakis A., Berl S. and Clarke D.D.: Purification and characterization of a soluble and a particulate glutamate dehydrogenase from rat brain. J. Neurochem. 46, 1811-1819 (1986)

108. Plaitakis A., Berl S. & Yahr M.D. Neurological disorders associated with deficiency of glutamate dehydrogenase. Ann. Neurol. 15, 144-153 (1984)

109. Frieden C.: In "The role of nucleotides for the function and conformation of enzymes" (H.M. Kalckar et al., eds.), p. 194. Munksgaard. Copenhagen (1969)

110. Moon K. & Smith E.L.: Sequence of bovine liver glutamate dehydrogenase. 8. Peptides produced by specific chemical cleavages; the complete sequence of the protein. J. Biol. Chem. 248(9), 3082-3088 (1973)

111. Dennis S.C. & Clark J.B.: The pathway of glutamate metabolism in rat brain mitochondria. Biochem. J. 168, 521-527 (1977)

112. Obaru K., Tsuzuki T., Shimada C. & Shimada K. (1986) Structural organization of the mouse aspartate aminotransferase isoenzyme genes. Introns antedate the divergence of cytosolic and mitochondrial isoenzyme genes. J. Mol. Biol. 200, 13-22 (1986)

113. Erecinska M. & Silver I.A.: Metabolism and role of glutamate in mammalian brain. Prog. Neurobiol. 35, 245-296 (1990)

114. García R.A.G. & Villegas J.: Aspartate aminotransferase and glutamate dehydrogenase activities in the squid giant nerve. J. Neurochem. 64, 437-442 (1995)

115. Homola A.D. & Dekker E.E.: Decarboxylation of gamma-hydroxyglutamate by glutamate decarboxylase of Escherichia coli (ATCC 11246) Biochemistry 6(8), 2626-2634 (1967)

116. Choi D.W., Maulucci-Gedde M. &Kriegstein A.R.: Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7(2), 357-368 (1987)

117. Pomara N., Singh R., Deptula D., Chou J.C.-Y., Schwartz M.B. & LeWitt P.A.: Glutamate and other CSF amino acids in Alzheimer’s disease. Am. J. Psychiatry 149, 251-254 (1992)

118. Perry T.L. & Hansen S.: What excitotoxin kills striatal neurons in Huntington’s disease? Clues from neurochemical studies. Neurology 40, 20-24 (1990)

119. Plaitakis AP, Constantakakis E. & Smith J.: The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis. Ann. Neurol. 24, 446-449 (1988)

120. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P. & Welty D.F.: Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675-686 (1996)

121. Szatkowski M. & Attwell D.: Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17(9), 359-365 (1994)

122. Cedarbaum J.M., Sheu K.-F.R., Harding B.J., Blass J.P., Javoy-Agid F. & Agid Y.: Deficiency of glutamate dehydrogenase in postmortem brain samples from parkinsonian putamen. Annals Neurol. 28(1), 111-112 (1990)

123. Rothstein, J.D., Van Kammen, M., Levey, A.I., Martin, L., Kunel, R.W. (1995) Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38:73-84.

124. Marangos W.F., Greenamyre J.T., Penny J.B., Young A.B.: Glutamate dysfunction in Alzheimer’s disease: an hypothesis. Trends Neurosci. 10, 65-68 (1987)

125. Arai H., Kobayashi K., Ichimiya Y., Kosaka K. & Iisuka R.: Free amino acids in post-mortem cerebral cortices from patients with Alzheimer-type dementia. Neurosci. Res. 2, 486-490 (1985)

126. Procter A.W., Palmer A.M., Francis P.T., Lowe S.L., Neary D., Murphy E., Doshi R. & Bowen D.M.: Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer’s disease. J. Neurochem. 50, 790-802 (1988)

127. Hyman B.T., VanHoeren G.W. & Damasio A.R.: Alzheimer’s disease: glutamate depletion in the hippocampal perforant pathway zone. Ann. Neurol. 22, 37-38 (1987)

128. Reynolds G.P. & Pearson S.J.: Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington’s disease brain. Neurosci. Lett. 78, 233-238 (1987)

129. Cross A.J., Slater P. & Reynolds G.P.: Reduced high affinity glutamate uptake sites in the brains of patients with Huntington’s disease. Neurosci. Lett. 67, 198-202 (1986)

130. Schapira A.H., Cooper J.M., Dexter D., Jenner P., Clark J.B. & Marsden C.D.: Mitochondrial complex I deficiency in Parkinson’s disease. Lancet 1, 1269 (1989)

131. Bindoff-L.A., Birch-Machin M., Cartlidge N.E., Parker W.D. Jr. & Turnbull D.M.: Mitochondrial dysfunction in Parkinson’s disease. Lancet 2, 49 (1989)

132. Clow D.W. & Jhamandas K.J.: Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen. J. Pharmacol. Exp. Ther. 248, 722-728 (1989)

133. Rothstein J.D., Jin L, Dykes-Hoberg M. & Kuncl R.W.: Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl. Acad. Sci. USA 90, 6591-6595 (1993)

134. Trotti D., Rossi D., Gjesdal O., Levy L.M., Racagmi G., Danbolt N.C. & Volterra A.: Peroxynitrite inhibits glutamate transporter subtypes. J. Biol. Chem. 271(11), 5976-5979 (1996)

135. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J. & O'Regan J.P.: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993 Jul 22;364(6435), 362 (1993)

136. Moreno J.J. & Pryor W.A.: Inactivation of alpha 1-proteinase inhibitor by peroxynitrite. Chem. Res. Toxicol. 5:425-431 (1992)

137. Nicholls D. & Attwell D.: The release and uptake of excitatory amino acids. Trends Pharmacol Sci. 11(11), 462-468 (1990)

138. Attwell D., Barbour B., Szatkowski M.: Nonvesicular release of neurotransmitter. Neuron 11:401-407 (1993)