[Frontiers in Bioscience, d701-718, July 20, 1998]
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EXCITATORY AMINO ACID NEUROTRANSMISSION. PATHWAYS FOR METABOLISM, STORAGE AND REUPTAKE OF GLUTAMATE IN BRAIN

Monica Palmada and Josep Joan Centelles

Departament de Bioquímica i Biologia Molecular, Facultat de Química, Universitat de Barcelona, Martí i Franquès, 1, 08028-Barcelona, Spain

Received 5/7/98 Accepted 5/23/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Excitatory amino acids receptors
3.1. Ionotropic glutamate receptors
3.1.1. NMDA receptors
3.1.2. Non-NMDA receptors
3.2. Metabotropic glutamate receptors

4. Excitatory amino acids transporters
4.1. EAAT1 and GLAST1
4.2. EAAT2 and GLT-1
4.3. EAAT3 and EAAC1
4.4. EAAT4
4.5. EAAT5
4.6. Synaptic vesicles glutamate transporter

5. Metabolic interactions between neurons and astrocytes
5.1. Glutamine synthetase (E.C. 6.3.1.2.)
5.2. Glutaminase (E.C. 3.5.1.2.)
5.3. Glutamate dehydrogenase (E.C. 1.4.1.2.-4.)
5.4. Transaminases
5.5. Glutamic acid decarboxylase (E.C. 4.1.1.15.)

6. Dysfunction of excitatory amino acid neurotransmission
7. References
8. Entire manuscript

Key words: Glutamate, Receptors, Transport, Metabolism, Neurotransmission, Neurodegeneration, Brain

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