[Frontiers in Bioscience 3, d59-99, January 15, 1998]

	[Frontiers in Bioscience 3, d59-99, January 15, 1998] Reprints PubMed CAVEAT LECTOR
	T CELLS AND AGING Graham Pawelec ¹, Ed Remarque ², Yvonne Barnett ³, Rafael Solana⁴ 1 University of Tübingen, Tübingen, FRG ²,University of Leiden, Leiden, Holland ³, University of Ulster, Coleraine, Northern Ireland ⁴, University of Córdoba, Córdoba, Spain Received 12/29/97 Accepted 1/5/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. What is immunosenescence? 4. Possible causes of immunosenescence 4.1 Haematopoiesis 4.2 Thymus 4.3 Post-thymic aging 5. Mechanisms contributing to immunosenescence 5.1 Accessory cells 5.2 Alterations in signal transduction 5.3 Defects in costimulatory pathways 5.4 Alterations in cytokine production and response 6. Culture models for immunosenescence: the Hayflick Limit applies to normal T cells. 7. Does telomeric end loss contribute to the replicative senescence of normal T cells? 8. Alterations in T cell subsets and markers with aging: is the senescent phenotype due to increases in memory cells and to their "clonal exhaustion"? 8.1 Longevity of naive and memory cells 8.2 Activation-induced cell death and aging 9. Clinical relevance of immunosenescence? 10. Predictors of mortality and longevity 11. Possible approaches to interventionist manipulations 11.1 Vitamins and minerals 11.2 Hormones 11.3 Antioxidants 11.4 Caloric restriction 11.5 Mutations and DNA repair 12. Perspective 13. Acknowledgements 14. References 15. Entire manuscript Key words: T cells, Aging, Immunosenescence, Immune response, Immunogerontology Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d59-99, January 15, 1998]
Reprints
PubMed
CAVEAT LECTOR

T CELLS AND AGING

Graham Pawelec ¹, Ed Remarque ², Yvonne Barnett ³, Rafael Solana⁴

1 University of Tübingen, Tübingen, FRG ²,University of Leiden, Leiden, Holland ³, University of Ulster, Coleraine, Northern Ireland ⁴, University of Córdoba, Córdoba, Spain

Received 12/29/97 Accepted 1/5/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. What is immunosenescence?
4. Possible causes of immunosenescence: 4.1 Haematopoiesis
4.2 Thymus
4.3 Post-thymic aging
5. Mechanisms contributing to immunosenescence: 5.1 Accessory cells
5.2 Alterations in signal transduction
5.3 Defects in costimulatory pathways
5.4 Alterations in cytokine production and response
6. Culture models for immunosenescence: the Hayflick Limit applies to normal T cells.
7. Does telomeric end loss contribute to the replicative senescence of normal T cells?
8. Alterations in T cell subsets and markers with aging: is the senescent phenotype due to increases in memory cells and to their "clonal exhaustion"?: 8.1 Longevity of naive and memory cells
8.2 Activation-induced cell death and aging
9. Clinical relevance of immunosenescence?
10. Predictors of mortality and longevity
11. Possible approaches to interventionist manipulations: 11.1 Vitamins and minerals
11.2 Hormones
11.3 Antioxidants
11.4 Caloric restriction
11.5 Mutations and DNA repair
12. Perspective
13. Acknowledgements
14. References
15. Entire manuscript

Key words: T cells, Aging, Immunosenescence, Immune response, Immunogerontology

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.