T CELLS AND AGING
Graham Pawelec 1, Ed Remarque 2, Yvonne Barnett 3, Rafael Solana 4
1 University of Tübingen, Tübingen, FRG 2, University of Leiden, Leiden, Holland 3, University of Ulster, Coleraine, Northern Ireland 4, University of Córdoba, Córdoba, Spain
Received 12/29/97 Accepted 1/5/97
TABLE OF CONTENTS
Key words: T cells, Aging, Immunosenescence, Immune response, Immunogerontology
- 1. Abstract
- 2. Introduction
- 3. What is immunosenescence?
- 4. Possible causes of immunosenescence
- 4.1 Haematopoiesis
4.3 Post-thymic aging
- 5. Mechanisms contributing to immunosenescence
- 5.1 Accessory cells
5.2 Alterations in signal transduction
5.3 Defects in costimulatory pathways
5.4 Alterations in cytokine production and response
- 6. Culture models for immunosenescence: the Hayflick Limit applies to normal T cells.
- 7. Does telomeric end loss contribute to the replicative senescence of normal T cells?
- 8. Alterations in T cell subsets and markers with aging: is the senescent phenotype due to increases in memory cells and to their "clonal exhaustion"?
- 8.1 Longevity of naive and memory cells
8.2 Activation-induced cell death and aging
- 9. Clinical relevance of immunosenescence?
- 10. Predictors of mortality and longevity
- 11. Possible approaches to interventionist manipulations
- 11.1 Vitamins and minerals
11.4 Caloric restriction
11.5 Mutations and DNA repair
- 12. Perspective
- 13. Acknowledgements
- 14. References
- 15. Entire manuscript
Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.