[Frontiers in Bioscience, 3 d152-168, February 1, 1998]
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REGULATION OF TRANSCRIPTION FACTOR NF KAPPA B IN IMMUNE SENESCENCE

Usha Ponnappan

Department of Geriatrics, Medicine, Microbiology and Immunology, University of Arkansas for Medical Sciences, and GRECC, John L. McClellan Memorial VA hospital, VA Medical Research, GC143, 151/LR, 4300 West 7th street, Little Rock, Arkansas 72205

Received 1/15/97 Accepted 1/29/98

TABLE OF CONTENTS

1. Abstract
2 Introduction: Aging and Immune function
2.1. T Lymphocyte function in Immune senescence
3 Transcription factor NF kappa B
3.1. Inhibitor of Kappa B: I kappa B
4.Signals and signaling pathways for NF kappa B
4.1.Modification and degradation of I kappa B
4.2. Autoregulation of NF kappa B and I kappa B
4.3.Role of NF kappa B in immune response

5. NF kappa B and immune senescence
6. Conclusions and Perspectives
7. Acknowledgment
8. References
9. Entire manuscript

Key words: Immunology, Immune function, Aging, Immune senesence, NF kappa B, I kappa B, Proteasome, Ubiquitin mediated degradation, T lymphocytes, TNF-alpha, Phosphorylation, Immune response, Cytokines, Signal transduction, rel family, c-rel, RelB, p50, p65, Memory and naive T cell subsets, IL-2, IL-2 receptor-alpha, Autoimmunity, Immune dysregulation

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