[Frontiers in Bioscience 3, d650-656, July 1, 1998]
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CAVEAT LECTOR




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THE CD44 PROTEIN FAMILY: ROLES IN EMBRYOGENESIS AND TUMOR PROGRESSION

Helmut Ponta1 and Peter Herrlich1,2

1 Forschungszentrum Karlsruhe, Institute of Genetics, and 2 University of Karlsruhe, Institute of Genetics, Postfach 3640, D-76021 Karlsruhe, Germany

Received 4/27/98 Accepted 5/12/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. CD44 functions
3.1. CD44 in lymphocyte rolling
3.2. CD44s in tumorigenesis
3.3. CD44v in metastasis formation
3.4. CD44v on lymphocytes
3.5. CD44v in dendritic cells
3.6. CD44v in keratinocytes
3.7. CD44 in embryogenesis
3.8. CD44 growth factor presentation in tumorigenesis: a hypothesis
3.9. CD44 variant splicing mediated by a composite splice element
4. Perspectives
5. Acknowledgments
6. References
7. Entire manuscript

Key words: Alternative Splicing, Limb Formation, Apical Ectodermal Ridge, Growth Factor Presentation, Metastasis Formation

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