[Frontiers in Bioscience 3, d665-671, July 1, 1998]
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CAVEAT LECTOR




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ROLE OF CD44 IN CTL AND NK CELL ACTIVITY

Asimah Q. Rafi-Janajreh, Prakash S. Nagarkatti and Mitzi Nagarkatti

Departments of Biology and Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061

Received 6/11/98 Accepted 6/17/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Adhesion molecules
4. Significance of CD44
5. Are cytotoxic lymphocytes involved in nonspecific vascular tissue injury seen in vivo?
5.1. Is CD44 Involved in the Induction of vascular leak syndrome (VLS)?
5.2 TCR-independent, MHC-unrestricted killing and its significance
5.3. Role of CD44 and various isoforms in T cell activation and MHC-unrestricted lysis
6. Conclusions
7. Acknowledgement
8. References
9. Entire manuscript

Key words: Cytotoxic T lymphocyte (CTL), Natural killer cell (NK), Vascular Leak Syndrome (VLS), Endothelial cell

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