[Frontiers in Bioscience 3, d913-921, August 6, 1998]
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CAVEAT LECTOR




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IS EXPOSURE TO ENVIRONMENTAL OR INDUSTRIAL ENDOCRINE DISRUPTING ESTROGEN-LIKE CHEMICALS ABLE TO CAUSE GENOMIC INSTABILITY?

Deodutta Roy, John B. Colerangle and Kamleshwar Prasad Singh

Department of Environmental Health Sciences, The University of Alabama at Birmingham, Birmingham, Alabama 35294-0008

Received 12/15/97Accepted 7/15/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Numerical changes in the genome
4. Structural changes in the genome
4.1. Covalent interaction with the genome
4.2. Telomeric loss
4.3. Telomeric associations
4.4. Chromatid/chromosomal breaks
5. Impaired expression of transcription-regulating and DNA repair proteins and protooncoproteins indicating genomic instability
6. Acknowledgment
7. References
8. Entire manuscript

Key words: Endocrine disruptors, Estrogen, Genome, Instability

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