[Frontiers in Bioscience 3, d1209-1219, December 1, 1998]

	[Frontiers in Bioscience 3, d1209-1219, December 1, 1998] Reprints PubMed CAVEAT LECTOR
	PROTEIN PHOSPHATASE TYPE 1, THE PRODUCT OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE, AND CELL CYCLE CONTROL Ethel Rubin¹, Sama Tamrakar¹, and John W. Ludlow^1,2 1Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, and ²University of Rochester Cancer Center, Rochester, New York 14642 Received 9/2/98 Accepted 11/17/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Regulation of the mammalian cell cycle 4. The role of pRb in cell cycle control - an overview 5. The structure and function of pRb 6. Biological significance: the cell cycle regulators and cancer 6.1. Cyclins/cdk 6.2. Cdk inhibitors 6.3. The pRb pathway 7. The dephosphorylation of pRb 8. PP1 regulation 9. Cell cycle regulation during hypoxia - synergy between kinase and phosphatase activity 10. Perspective 11. Acknowledgments 12. References 13. Entire manuscript Key words: Serine/Threonine Protein Phosphatase, Protein Phosphatase Type 1 (PP1), pRb, Cyclin-Dependent Kinase Activity, Mammalian Cell Cycle Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d1209-1219, December 1, 1998]
Reprints
PubMed
CAVEAT LECTOR

PROTEIN PHOSPHATASE TYPE 1, THE PRODUCT OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE, AND CELL CYCLE CONTROL

Ethel Rubin¹, Sama Tamrakar¹, and John W. Ludlow^1,2

1Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, and ²University of Rochester Cancer Center, Rochester, New York 14642

Received 9/2/98 Accepted 11/17/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Regulation of the mammalian cell cycle
4. The role of pRb in cell cycle control - an overview
5. The structure and function of pRb
6. Biological significance: the cell cycle regulators and cancer: 6.1. Cyclins/cdk
6.2. Cdk inhibitors
6.3. The pRb pathway
7. The dephosphorylation of pRb
8. PP1 regulation
9. Cell cycle regulation during hypoxia - synergy between kinase and phosphatase activity
10. Perspective
11. Acknowledgments
12. References
13. Entire manuscript

Key words: Serine/Threonine Protein Phosphatase, Protein Phosphatase Type 1 (PP1), pRb, Cyclin-Dependent Kinase Activity, Mammalian Cell Cycle

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.