[Frontiers in Bioscience 3, d1209-1219, December 1, 1998]
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CAVEAT LECTOR




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PROTEIN PHOSPHATASE TYPE 1, THE PRODUCT OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE, AND CELL CYCLE CONTROL

Ethel Rubin1, Sama Tamrakar1, and John W. Ludlow1,2

1Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, and 2University of Rochester Cancer Center, Rochester, New York 14642

Received 9/2/98 Accepted 11/17/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Regulation of the mammalian cell cycle
4. The role of pRb in cell cycle control - an overview
5. The structure and function of pRb
6. Biological significance: the cell cycle regulators and cancer
6.1. Cyclins/cdk
6.2. Cdk inhibitors
6.3. The pRb pathway
7. The dephosphorylation of pRb
8. PP1 regulation
9. Cell cycle regulation during hypoxia - synergy between kinase and phosphatase activity
10. Perspective
11. Acknowledgments
12. References
13. Entire manuscript

Key words: Serine/Threonine Protein Phosphatase, Protein Phosphatase Type 1 (PP1), pRb, Cyclin-Dependent Kinase Activity, Mammalian Cell Cycle