[Frontiers in Bioscience 3, d944-960, September 1, 1998]
Reprints
PubMed
CAVEAT LECTOR




Table of Conents
 Previous Section   Next Section

BIOLOGICAL AND MOLECULAR BASIS OF HUMAN BREAST CANCER

Jose Russo, Xiaoqi Yang, Yun-Fu Hu, Betsy A. Bove, Yajue Huang, Ismael D.C.G. Silva, Quivo Tahin, Yuli Wu, Nadia Higgy, Abdel Zekri, and Irma H. Russo

Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

Received 12/17/97 Accepted 7/21/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Human Breast Epithelial Cells (HBEC) in Culture
4. Factors Influencing Susceptibility of HBEC to Cell Transformation
4.1. Lobular differentiation
4.2. Genetic predisposition
4.3. Cell immortalization
5. Molecular Mechanisms of Cell Immortalization
5.1. Activation of telomerase
5.2. Abrogation of cell cycle control
5.3. Genes preferentially expressed during cell immortalization
6. Molecular Mechanisms of Cell Transformation
6.1. Epigenetic mechanisms
6.2. Genetic mechanisms
7. Genomic changes in Immortalization and Transformation of HBEC
7.1. Genomic changes in cell immortalization
7.2. Genomic changes in cell transformation
8. Genomic Changes in Human Breast Lesions
9. Functional Roles of Chromosomes 11 and 17 in Transformed Phenotype Expression of HBEC
10. Summary and Perspectives
11. Acknowledgments
12. References
13. Entire manuscript

Key words: Human Breast Epithelial Cells (HBEC); Cell Immortalization; Cell Transformation; Progression Of Neoplastic Phenotype; Carcinogens; Gene Expression; Calcium; Ca-Binding Protein; Mammary-Derived Growth Inhibitor; H-Ferritin; Gene Mutation; TP53; C-Erbb2; Int-2; C-Myc; Mdm2; Microsatellite Instability; D11S912; D13S260; D13S289; D16S285; Chromosome 11; Chromosome 13; Chromosome 16; Chromosome 17; Microcell-Mediated Chromosome Transfer; Senescence; Growth Inhibition; Anchorage Independent Growth

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.

Enter one or more search keywords:

To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most