[Frontiers in Bioscience, 3, d459-467, April 27, 1998]
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THE NEUTRAL THEORY AND NATURAL SELECTION IN THE HLA REGION

Yoko Satta, Yi-Ju Li and Naoyuki Takahata

Department of Biosystems Science, The Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan

Received 4/3/98 Accepted 4/7/98

Table of contents

1. Abstract
2. Introduction
3. Genes and nucleotide differences in HLA
4. Intergenic recombination
5. DRB1 allelic lineages and disease association
6. Perspective
7. Acknowledgments
8. References
9. Entire manuscript

Key words:

Polymorphism, Nucleotide Differences, Balancing Selection, Allelic Lineage, Sequence Motifs, Recombination, Gene Conversion, Population Genetics, Major Histocompatibility Complex

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