TRANSCRIPTIONAL REGULATION OF ALPHA-1 ADRENERGIC RECEPTORS

Daniel R. Scanga¹ and Debra A. Schwinn^2,3,4

School of Medicine,¹ Departments of Anesthesiology,² Surgery,³ and Pharmacology/Cancer Biology, ⁴ Duke University Medical Center, Durham, NC 27710

Received 2/25/98 Accepted 3/2/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. 5’ untranslated region and putative regulatory consensus sequences
4. Identification of transcription initiation sites
5. Use of reporter constructs to define promoters
6. Transcription initiation in TATA-less promoters
7. Multiple promoters
8. Cell-specific expression of adrenergic receptor mRNAs
9. Modulation of gene expression via cis-acting elements
10. Perspectives
11. Acknowledgments
12. References
13. Entire manuscript

Key words: Receptor, Adrenergic, Alpha-adrenergic, Gene, 5' flanking region, cis regulatory element, Reporter construct, Transcriptional regulation