Frontiers in Bioscience 3, d1181-1186, November 15, 1998]
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THE TAO OF MEKK

Thomas K. Schlesinger1,2,3, Gary R. Fanger1, Toshi Yujiri1 and Gary L. Johnson1,2

1Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, 1400 Jackson St. Denver, CO 80206, 2Department of Pharmacology, 3MST Program* University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver CO 80226

Received 10/10/98 Accepted 10/22/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. MEKKs: cloning and regulation
4. MAPKs: regulation and biological role
5. Role of MEKK1 in apoptosis and cell survival
6. Regulation of NFkB by MEKK1
7. Acknowledgement
8. References
9. Entire manuscript

Key words: Phosphorylation, MEKK, NFkappaB, Protein kinase, Molecular biology, Cloning, Gene regulation

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