[Frontiers in Bioscience 3, d729-738, July 26, 1998]
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ENDOCYTOSIS AND INTRACELLULAR SORTING OF RECEPTOR TYROSINE KINASES

Alexander Sorkin

Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA

Received 5/29/98 Accepted 5/8/98

TABLE OF CONTENTS

1. Abstract
2. Introduction: Receptor-mediated endocytosis
3. Endocytosis of growth factor receptors: down-regulation
4. Internalization
4.1. Receptor recruitment into clathrin-coated pits
4.2. Molecular mechanisms of internalization
5. Intracellular sorting
5.1. Pathway through endosomes
5.2. Kinetics of intracellular trafficking: recycling versus degradation
5.3. Possible mechanisms of receptor sorting in endosomes
6. Role of endocytosis in growth factor signaling
7. Perspectives
8. Acknowledgments
9. References
10. Entire manuscript

Key words: Cell Biology; Mammalian Cells; Endocytosis; Intracellular Trafficking; Growth Factor Receptors

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