[Frontiers in Bioscience 3, d849-864, August 1, 1998]
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NUCLEAR STRUCTURE - SKELETAL GENE EXPRESSION INTERRELATIONSHIPS

Gary S. Stein, André J. van Wijnen, Janet L. Stein, Jane B. Lian

Department of Cell Biology and Cancer Center, University of Massachusetts Medical Center, 55 Lake Ave. North, Worcester, MA 01655

Received 2/6/98 Accepted 2/15/98

TABLE OF CONTENTS

1. Abstract
2. Introduction: An Assessment of the Requirements for Functional Interrelationships Between Nuclear Structure and Gene Expression
3. The Osteocalcin Gene as a Paradigm for Bone-Specific Transcriptional Control
3.1. Biological Parameters of Osteocalcin Gene Transcription
3.2. Functional Mapping of Osteocalcin Gene Promoter Domains
3.2.1. Basal/Tissue Specific Factors and Sequences
3.2.2. Multiple Glucocorticoid Responsive Promoter Domains
3.2.3. The Vitamin D Responsive Element
3.2.4. Additional Osteocalcin Gene Promoter Regulatory Sequences
3.2.5. Upstream Regulatory Sequences and In Vivo Regulation of Osteocalcin Expression
3.2.6. Regulatory Implications of Overlapping and Contiguous Regulatory Domains
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4. Nuclear Architecture Supports the Integration of Regulatory Signals Mediating Bone Tissue-Specific Transcription
4.1. Parameters of Nuclear Structure Contribute to Transcriptional Control
4.2. Developmental & Steroid Hormone Modifications of Osteocalcin Gene Chromatin Structure & Nucleosome Organization
4.3. Contributions of the Nuclear Matrix to Osteocalcin Gene Expression
4.4. The Organization and Activities of AML/CBF Transcription Factors Provide a Paradigm for Interrelationships of Nuclear Architecture with Transcriptional Control
5. Perspective
6. Acknowledgments
7. References
8. Entire manuscript

Key words: Transcription, Chromatin, Nucleosomes, Nuclear matrix