[Frontiers in Bioscience 3, d532-547, June 8, 1998]
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CAVEAT LECTOR




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NEW PERSPECTIVES ON RETINOBLASTOMA FAMILY FUNCTIONS IN DIFFERENTIATION

Amy S. Yee, Heather H. Shih, and Sergei G. Tevosian

The Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111

Received 5/10/98 Accepted 5/29/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1. General Background Of The RB Family
3. Discussion: Functions In Differentiation
3.1. Summary Of Knockout Mice
3.2. Differentiation Models
3.3. Role In Cell Cycle Exit
3.3.1. E2F
3.3.2. HBP1
3.3.3. Irreversibility of cell cycle exit

3.4. Role In Apoptosis Protection
3.5 Role In Tissue-Specific Gene Expression
3.5.1 Positive Regulation
3.5.2. Negative Regulation
3.5.2.1. HBP1
3.5.2.2. p202
3.5.2.3. CHOP
3.5.2.4. p130
4.Future Perspectives
4.1 Working Model: "A Differentiation Checkpoint?"
4.1.1. The Early Phase: Cell Cycle Exit and Apoptosis Protection
4.1.2. The Late Phase: Activation of Tissue-specific Gene Expression
4.2 Future Perspectives
5. Acknowledgments
6. References
7. Entire manuscript

Key words: Retinoblastoma, E2F, HBP1, p130, p107, Differentiation, Apoptosis

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