[Frontiers in Bioscience 3, d877-886, August 5, 1998]
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CONSERVED FUNCTIONS OF THE CYTOPLASMIC DOMAINS OF INTEGRIN BETA SUBUNITS

Jari Ylänne

Department of Biosciences, Division of Biochemistry, and Institute of Biotechnology, Viikki Biocenter, University of Helsinki

Received 6/14/98 Accepted 6/22/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. The classification of the cytoplasmic domains of integrin beta subunits
4. The primary structures of the beta1-like cytoplasmic domains
5. Hints of the 3-dimensional structures
6. Molecules interacting with the beta1-like cytoplasmic domains
7. Conserved functions of the beta1-like cytoplasmic domains
7.1. Cytoskeletal anchorage and assembly
7.2. Trans-dominant inhibition of function
7.3. Signalling functions
8. Correlation between common binding proteins and common function
9. Perspectives
10. Acknowledgements
11. References
12. Entire manuscript
Key words: Integrin, Cell Adhesion, Cytoskeleton, Signal Transduction

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