[Frontiers in Bioscience 3, e164-174, October 1, 1998]
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MYCOBACTERIAL LIPIDS : A HISTORICAL PERSPECTIVE

Jean Asselineau and Gilbert Lanéelle1

Université Paul Sabatier (Toulouse 3)1 and Institut de Pharmacologie et de Biologie Structurale du CNRS, 205 route de Narbonne, 31077 Toulouse, Cedex, France

Received 8/3/98 Accepted 8/14/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Mycolic acids
3.1. Historical introduction
3.2. Structure: present status
3.2.1. Mycolic acids without oxygen function in the mero part
3.2.2. Mycolic acids with an oxygenated function in the mero part

3.3. Biosynthesis
3.3.1. Condensation
3.3.2. Elongation
3.3.3. Biosynthesis from four acid molecules
4. Acyl trehaloses
4.1.  Cord factor 
4.2. Polyacyl trehaloses
4.2.1. Sulfolipids (SL)
4.2.2. Di- and tri-acyl trehaloses (DAT, TAT)
5. Oligosaccharide-containing lipids
5.1. Lipooligosaccharides (LOS)
5.2.  Mycosides 
5.2.1. Phenolglycolipids (PGL)
5.2.2. Glycopeptidolipids (GPL)
6. Glycosyl derivatives of phosphatidylinositol
6.1. Phosphatidyl-inositomannosides (PIM)
6.2. Lipomannans (LM) and lipoarabinomannans (LAM)
7. Coda
8. References
9. Entire manuscript

Key words: Infection, Mycobacteria, Active Lipids, Glycolipids

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