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CLINICAL IMPLICATIONS OF ANOMALOUS CD44 GENE EXPRESSION IN NEOPLASIA
Steve Goodison and David Tarin
UCSD Cancer Center 9500 Gilman Drive La Jolla California 92093 USA
Received 4/27/98 Accepted 5/12/98
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. CD44 expression in normal tissues
- 4. CD44 expression in neoplasia
- 4.1. Breast
4.2. Lung
4.3. Gastrointestinal
4.4. Uterine cervix
4.5. Lymphoid tissue
4.6. Urological
4.7. Other tumors
4.8. Aberrant processing of CD44 transcripts
4.9. CD44 in neoplasia
4.10. CD44 in metastasis
- 5. Clinical implications
- 5.1. Early cancer diagnosis
- 5.1.1. Colon
5.1.2. Urine
5.1.3. Soluble CD44
5.1.4. Summary of diagnostic applications
- 5.2 Prognosis
- 5.2.1. Colon
5.2.2. Breast
5.2.3. Cervix
5.2.4. Summary of prognostic applications
6. Perspectives
7. References
7. Entire manuscript
Key words: CD44, Gene expression patterns, RNA processing, Neoplasia, Tumor
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