[Frontiers in Bioscience, 3, e49-69, May 5, 1998]
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THERAPEUTIC ANGIOGENESIS

Jeffrey M. Isner, and Takayuki Asahara

Departments of Medicine (Cardiology) and Biomedical Research, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA.

Received 4/6/98 Accepted 4/29/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. Vasculogenesis and angiogenesis
3.1.1. Classic paradigm for angiogenesis
3.1.2. Ligand-receptor systems modulate vasculogenesis and angiogenesis
3.1.3. Remodeling
3.1.4. Nascent vessels
3.1.5. Matrix-integrin interactions
3.1.6. Vasculogenesis in the adult
3.2. Angiogenic cytokines
3.2.1 autocrine loop as a feature of angiogenic cytokines <
3.2.2. Direct versus indirect cytokines
3.2.3. Site-specific effects of angiogenic cytokines
3.3. Therapeutic angiogenesis
3.3.1. Therapeutic angiogenesis preserves vasomotor reactivity of collateral vessels
3.3.2. Therapeutic angiogenesis achieved by arterial gene transfer
3.3.3. Recombinant protein versus gene therapy
4. Perspectives
5. Acknowledgements
6. References
7. Entire manuscript

Key words: Angiogenesis, Vasculogenesis, Collateral vessels, Gene therapy, Endothelial cells, VEGF

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