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THERAPEUTIC ANGIOGENESIS
Jeffrey M. Isner, and Takayuki Asahara
Departments of Medicine (Cardiology) and Biomedical Research, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA.
Received 4/6/98 Accepted 4/29/98
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Discussion
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3.1. Vasculogenesis and angiogenesis
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3.1.1. Classic paradigm for angiogenesis
3.1.2. Ligand-receptor systems modulate vasculogenesis and angiogenesis
3.1.3. Remodeling
3.1.4. Nascent vessels
3.1.5. Matrix-integrin interactions
3.1.6. Vasculogenesis in the adult
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3.2. Angiogenic cytokines
- 3.2.1 autocrine loop as a feature of angiogenic cytokines
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3.2.2. Direct versus indirect cytokines
3.2.3. Site-specific effects of angiogenic cytokines
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3.3. Therapeutic angiogenesis
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3.3.1. Therapeutic angiogenesis preserves vasomotor reactivity of collateral vessels
3.3.2. Therapeutic angiogenesis achieved by arterial gene transfer
3.3.3. Recombinant protein versus gene therapy
- 4. Perspectives
- 5. Acknowledgements
- 6. References
- 7. Entire manuscript
Key words: Angiogenesis, Vasculogenesis, Collateral vessels, Gene therapy, Endothelial cells, VEGF
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