[Frontiers in Bioscience 3, e81-88, June 8, 1998]

	[Frontiers in Bioscience 3, e81-88, June 8, 1998] Reprints PubMed CAVEAT LECTOR
	ROLE OF LIPOXYGENASES IN BREAST CANCER Rama Natarajan and Jerry Nadler Department of Diabetes, Endocrinology and Metabolism¹,City of Hope National Medical Center, 1500, E. Duarte Road, Duarte, California 91010, USA. Received 5/15/98 Accepted 5/29/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Arachidonic acid Metabolism and the Lipoxygenases 4. Regulation of Lipoxygenase (LO) by Growth Factors and Cytokines 5. Actions of Lipoxygenase products related to Cell Growth and Adhesion 6. Expression and Regulation of 12-LO in Breast Cancer Cells and Tissues 6.1 Leukocyte-type 12-LO mRNA expression in breast tissue samples 6.2 Human 15-LO mRNA expression in breast tissue samples 6.3 12-LO mRNA and Protein expression in breast cancer and normal breast cell lines 6.4 The effect of EGF on cell-associated 12(S)-HETE levels 6.5 The effect of EGF on 12-LO protein expression. 6.6 The effect of LO and cyclooxygenase inhibitors on the growth of MCF-7 cells 7. Mechanisms involved in LO product-mediated breast cancer development 8. Perspective 9. Acknowledgments 10. References 11. Entire manuscript Key words: Lipoxygenase, Cancer, Breast, Growth factors, Epidermal growth factor, 12-HETE, PCR Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, e81-88, June 8, 1998]
Reprints
PubMed
CAVEAT LECTOR

ROLE OF LIPOXYGENASES IN BREAST CANCER

Rama Natarajan and Jerry Nadler

Department of Diabetes, Endocrinology and Metabolism¹,City of Hope National Medical Center, 1500, E. Duarte Road, Duarte, California 91010, USA.

Received 5/15/98 Accepted 5/29/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Arachidonic acid Metabolism and the Lipoxygenases 4. Regulation of Lipoxygenase (LO) by Growth Factors and Cytokines
5. Actions of Lipoxygenase products related to Cell Growth and Adhesion: 6. Expression and Regulation of 12-LO in Breast Cancer Cells and Tissues
6.1 Leukocyte-type 12-LO mRNA expression in breast tissue samples
6.2 Human 15-LO mRNA expression in breast tissue samples
6.3 12-LO mRNA and Protein expression in breast cancer and normal breast cell lines
6.4 The effect of EGF on cell-associated 12(S)-HETE levels
6.5 The effect of EGF on 12-LO protein expression.
6.6 The effect of LO and cyclooxygenase inhibitors on the growth of MCF-7 cells
7. Mechanisms involved in LO product-mediated breast cancer development
8. Perspective
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Lipoxygenase, Cancer, Breast, Growth factors, Epidermal growth factor, 12-HETE, PCR

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.