[Frontiers in Bioscience 3, e81-88, June 8, 1998]
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ROLE OF LIPOXYGENASES IN BREAST CANCER

Rama Natarajan and Jerry Nadler

Department of Diabetes, Endocrinology and Metabolism1, City of Hope National Medical Center, 1500, E. Duarte Road, Duarte, California 91010, USA.

Received 5/15/98 Accepted 5/29/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Arachidonic acid Metabolism and the Lipoxygenases
4. Regulation of Lipoxygenase (LO) by Growth Factors and Cytokines
5. Actions of Lipoxygenase products related to Cell Growth and Adhesion
6. Expression and Regulation of 12-LO in Breast Cancer Cells and Tissues
6.1 Leukocyte-type 12-LO mRNA expression in breast tissue samples
6.2 Human 15-LO mRNA expression in breast tissue samples
6.3 12-LO mRNA and Protein expression in breast cancer and normal breast cell lines
6.4 The effect of EGF on cell-associated 12(S)-HETE levels
6.5 The effect of EGF on 12-LO protein expression.
6.6 The effect of LO and cyclooxygenase inhibitors on the growth of MCF-7 cells
7. Mechanisms involved in LO product-mediated breast cancer development
8. Perspective
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Lipoxygenase, Cancer, Breast, Growth factors, Epidermal growth factor, 12-HETE, PCR

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