[Frontiers in Bioscience 3, e39-48, April 30, 1998]

	[Frontiers in Bioscience 3, e39-48, April 30, 1998] Reprints PubMed CAVEAT LECTOR
	TESTIS - SPECIFIC PROTEINS AND THEIR ROLE IN CONTRACEPTIVE VACCINE DEVELOPMENT Rajesh K. Naz and Cynthia M. Vanek Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Richard D. Ruppert Health Center, 3120 Glendale Avenue, Toledo, OH 43614-5809, USA Received 3/30/98 Accepted 4/27/98 1. ABSTRACT Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its testis/sperm specificity and involvement in spermatogenesis and/or fertilization. The aim of the present article is to review the information regarding the proteins that have been reported to be testis/sperm-specific and may have an important function in spermatogenesis and/or fertilization. The potential role of these proteins in the development an antisperm contraceptive vaccine(s) is discussed.

[Frontiers in Bioscience 3, e39-48, April 30, 1998]
Reprints
PubMed
CAVEAT LECTOR

TESTIS - SPECIFIC PROTEINS AND THEIR ROLE IN CONTRACEPTIVE VACCINE DEVELOPMENT

Rajesh K. Naz and Cynthia M. Vanek

Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Richard D. Ruppert Health Center, 3120 Glendale Avenue, Toledo, OH 43614-5809, USA

Received 3/30/98 Accepted 4/27/98

1. ABSTRACT

Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its testis/sperm specificity and involvement in spermatogenesis and/or fertilization. The aim of the present article is to review the information regarding the proteins that have been reported to be testis/sperm-specific and may have an important function in spermatogenesis and/or fertilization. The potential role of these proteins in the development an antisperm contraceptive vaccine(s) is discussed.