[Frontiers in Bioscience 3, e39-48, April 30, 1998] |
TESTIS - SPECIFIC PROTEINS AND THEIR ROLE IN CONTRACEPTIVE VACCINE DEVELOPMENT
Rajesh K. Naz and Cynthia M. Vanek
Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Richard D. Ruppert Health Center, 3120 Glendale Avenue, Toledo, OH 43614-5809, USA
Received 3/30/98 Accepted 4/27/98
Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its testis/sperm specificity and involvement in spermatogenesis and/or fertilization. The aim of the present article is to review the information regarding the proteins that have been reported to be testis/sperm-specific and may have an important function in spermatogenesis and/or fertilization. The potential role of these proteins in the development an antisperm contraceptive vaccine(s) is discussed.