[Frontiers in Bioscience 3, e39-48, April 30, 1998] |
TESTIS - SPECIFIC PROTEINS AND THEIR ROLE IN CONTRACEPTIVE VACCINE DEVELOPMENT
Rajesh K. Naz and Cynthia M. Vanek
Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Richard D. Ruppert Health Center, 3120 Glendale Avenue, Toledo, OH 43614-5809, USA
Received 3/30/98 Accepted 4/27/98
In conclusion, the testis-specific proteins that are expressed on the mature sperm cell surface and have a crucial role in sperm function and fertilization are interesting candidates for the development of a contraceptive vaccine. The testis-specific proteins that are present inside the cell but have an important role in spermatogenesis/spermiogenesis, unless expressed on the
mature sperm surface will have limited applications in the ACV development. However, inhibition of the synthesis by antisense oligonucleotide approach may provide a viable method for contraception in men. The oligonucleotides because of their smaller size should be able to cross the blood-testis barrier as well as the membrane of the developing germ cells. Further studies are needed to test this hypothesis and feasibility of the antisense oligonucleotide approach.