[Frontiers in Bioscience, 3, e23-38, April 27, 98]
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CAVEAT LECTOR




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VASCULAR SMOOTH MUSCLE, ENDOTHELIAL REGULATION AND EFFECTS OF ASPIRIN IN HYPERTENSION

Munir A. Rahmani

Division of Science and Mathematics, Bethune-Cookman College, Daytona Beach, FL 32114

Received 3/25/98 Accepted 3/30/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Regulation of VSM Contraction and Relaxation
4. Endothelial Mediation
4.1. Endothelins
4.2. Arachidonic Acid Metabolites
4.3. Nitric Oxide
5. Endothelium in Hypertension
6. Aspirin and its Therapeutic Usage
6.1. Role of Cyclooxygenase in Pharmacology of Aspirin
6.1.1. Effects of Cyclooxygenase Inhibition in SHR and WKY rats
6.2. Effects of Aspirin on Vasoreactivity
6.2.1. In Vitro Effects
6.2.1.1. Vasoreactivity of aortic rings with intact endothelium
6.2.1.2. Vasoreactivity of aortic rings denuded of endothelium
6.2.2. In Vivo Effects
6.2.2.1. Intraperitoneal administration of ASA and aortic Contractility in Female SHR Rats
6.2.2.2. Effects of in vivo administration on aortic contractility and blood pressure in male SHR rats
6.2.2.3. Ca2+ Conductance as Measured by Active Tension Generated by Aortic Rings
6.2.2.4. Effects of ASA on Systolic Blood Pressure
7. Significance
8 Acknowledgments
9. References
10. Entire manuscript
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