[Frontiers in Bioscience 3, e238-246, December 15, 1998]
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TREATMENT OF SEVERE MALE INFERTILITY BY MICROMANIPULATION-ASSISTED FERTILIZATION:

NEWS AND VIEWS

Jan Tesarik1 , Carmen Mendoza2 and Ermanno Greco3

1Laboratoire d’Eylau, 55 rue Saint-Didier, 75116 Paris, France; 2Department of Biochemistry and Molecular Biology, University of Granada Faculty of Sciences, Campus Universitario Fuentenueva, 70018 Granada, Spain; and 3Centre of Assisted Reproduction, European Hospital, Rome, Italy

Received 11/11/98 Accepted 11/27/98

TABLE OF CONTENTS

1. Abstract
2. Evolution Of Micromanipulation-Assisted Fertilization Techniques And Their Use In Human Infertility Management
2.1. Rationale Underlying The Use Of Micromanipulation-Assisted Fertilization
2.2. Increasing Degree Of Assistance
2.3. Animal Experimentation And Human Application
3. Current Status Of Micromanipulation-Assisted Fertilization
3.1. Modifications Of Basic Biological Mechanisms Underlying Fertilization
3.1.1. Sperm Capacitation
3.1.2. Acrosome Reaction
3.1.3. Oocyte Activation
3.1.4. Manipulation Of Male Germ Cell Ploidy
3.2. Clinical Efficacy
3.2.1. Ejaculated Spermatozoa
3.2.2. Epididymal Spermatozoa
3.2.3. Testicular Spermatozoa
4. Real And Potential Health Hazards
4.1. Real Hazards
4.1.1. Transmission Of Gene Microdeletions/Mutations Causing Infertility
4.1.2. Chromosomal Abnormalities
4.2. Potential Hazards
5. New Developments And Future Directions
6. References
7. Entire manuscript

Key words: Infertility Micromanipulation, Treatment, Fertilization, Gametes